ArticleNutrients2019
Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Sustainable Ellagitannin-Rich Pomegranate Peel Extracts Activate SKN-1/NRF2-Dependent Antioxidant Responses and Promote Healthy Aging inAntioxidants (Basel, Switzerland) · 2026Article
- Comparative Profiling of Volatile Compounds and Fatty Acids in Pomegranate Seed Oil: Soxhlet vs. COFoods (Basel, Switzerland) · 2025Article
- Multifaceted Neuroprotective Role of Punicalagin: A Review.Neurochemical research · 2024Review
- Pomegranate Fruit Cracking during Maturation: From Waste to Valuable Fruits.Foods (Basel, Switzerland) · 2023Article
- ERp57/PDIA3: new insight.Cellular & molecular biology letters · 2022Review
- Effect of polyphenols extracted fromJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Review
- Study of Bio-Pharmaceutical and Antimicrobial Properties of Pomegranate (Plants (Basel, Switzerland) · 2021Article
- Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review.Bioresources and bioprocessing · 2021Review
- A new way for punicalagin to alleviate insulin resistance: regulating gut microbiota and autophagy.Food & nutrition research · 2021Article
- Urolithin A Inhibits Epithelial-Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway.OncoTargets and therapy · 2021Article
- The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis.Nutrients · 2020Review
- Dietary Bioactive Compounds and Human Health and Disease.Nutrients · 2020Article
- Antioxidant Action andAdvances in pharmacological and pharmaceutical sciences · 2020Article
- Punicalagin Prevents Inflammation in LPS-Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway.Nutrients · 2019Article
- Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel ofMolecules (Basel, Switzerland) · 2019Article
- A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion.International journal of molecular sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid, play a role as anti-atherogenic and neuroprotective molecules in the complex fighting against the degenerative diseases. The aim of this work was to evaluate the composition in punicalagins and ellagic acid of differently obtained extracts from whole fruit, peels and juices, prepared by squeezing or by centrifugation, of pomegranate belonging to different cultivars. Moreover, a wider phenolic fingerprint was also determined. The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer's and Parkinson's diseases. The results demonstrate that the different ratios between punicalagin and ellagic acid modulate the enzyme activity and other ellagitannins could interfere with this activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.