Evidence map›Paper›PMID 30658390›Full record

ReviewViruses2019

Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism.

Craig Schindewolf, Vineet D Menachery

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04420260 (Scheme of Primary Prevention of Infection by COVID-19, in Workers), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04420260 nacompletednot on this mapstarted 2021, after this paper: background citation

Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia

TypeinterventionalSponsorUnidad de Investigación Genética MolecularRan2021 to 2021Enrolled152ConditionsCOVIDArmsGroup A: oropharygeal spray and immunostimulant emulsion, Group D:Placebo oropharyngeal spray + Placebo taken PO
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Vaccines platforms and COVID-19: what you need to know.Tropical diseases, travel medicine and vaccines · 2022
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Vaccine design and delivery approaches for COVID-19.International immunopharmacology · 2021
    Review
  11. Flashback and lessons learnt from history of pandemics before COVID-19.Journal of family medicine and primary care · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Craig SchindewolfDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 TX, USA. crschind@UTMB.EDU.
Vineet D MenacheryDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 TX, USA. vimenach@utmb.edu.ORCID 0000-0001-8803-7606
The University of Texas Medical Branch at Galveston · US

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, HEISE, MARK T · 2012 to 2021
$36.6M
Systems Based Analysis of Host Factors that Contribute to Aging PathogenesisR00AG049092 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENACHERY, VINEET D · 2017 to 2019
$736k
National Institute of Allergy and Infectious Diseases U19AI100625NIA NIH HHS R00 AG049092NIA NIH HHS R00AG049092University of Texas Medical Branch McLaughlin Endowment
6 · The paper itself

Abstract

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralCoronavirus InfectionsDisease Models, AnimalHumansMiceMiddle East Respiratory Syndrome CoronavirusSpike Glycoprotein, CoronavirusVaccinationVaccines, AttenuatedViral VaccinesAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, CoronavirusVaccines, AttenuatedViral Vaccinesanimal modelscoronavirus spike glycoproteincorrelates of immunityMiddle East respiratory syndrome coronavirussevere acute respiratory syndrome coronavirusvaccine platforms

Identifiers

PMID30658390
PMCPMC6356267
OpenAlexW2910277765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.