Evidence map›Paper›PMID 30658110›Full record

ArticleCell chemical biology2019

Probing Substrate Preferences of Depalmitoylases.

Baoen Chen, Xu Wu

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Baoen ChenCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149, 13th St. Charlestown, MA 02129, USA.
Xu WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149, 13th St. Charlestown, MA 02129, USA. Electronic address: xwu@cbrc2.mgh.harvard.edu.

Funding

Chemical approach to study autopalmitoylation of transcription factorsR01DK107651 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LUO, XUELIAN, WU, XU · 2016 to 2020
$1.9M
Metabolic regulation of cellular junction proteinsR01CA181537 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WU, XU · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA181537NIDDK NIH HHS R01 DK107651
6 · The paper itself

Abstract

Depalmitoylases play a crucial role in regulating dynamic protein palmitoylation. In this issue of Cell Chemical Biology, Amara et al. (2019) present fluorogenic peptide probes to analyze the activity and substrate specificity of depalmitoylases and uncover that the amino acid residues distal to the palmitoylation site could regulate depalmitoylases activities.

Indexed as

Amino AcidsPeptidesSubstrate SpecificityAmino AcidsPeptides

Identifiers

PMID30658110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.