ArticleHuman pathology2019
Incidental nonneoplastic parenchymal findings in patients undergoing lung resection for mass lesions.
Article in Human pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Upfront uniportal anatomical segmentectomy: a propensity score-matched analysis on the early postoperative outcomes of complex and simple resections.Journal of thoracic disease · 2026Article
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.Tuberculosis and respiratory diseases · 2025Article
- Understanding cystic lung lesions in smokers with interstitial lung disease: radiologic-pathological correlation.Insights into imaging · 2025Article
- Interstitial Lung Abnormalities: Unraveling the Journey from Incidental Discovery to Clinical Significance.Diagnostics (Basel, Switzerland) · 2025Review
- Outcome of immune checkpoint inhibitor treatment in non-small cell lung cancer patients with interstitial lung abnormalities: clinical utility of subcategorizing interstitial lung abnormalities.Cancer immunology, immunotherapy : CII · 2024Article
- Frequency of subclinical interstitial lung disease in COVID-19 autopsy cases: potential risk factors of severe pneumonia.BMC pulmonary medicine · 2023Review
- Survival impact of fibrotic interstitial lung abnormalities in resected stage IA non-small cell lung cancer.The British journal of radiology · 2023Article
- Radiologic and Histologic Correlates of Early Interstitial Lung Changes in Explanted Lungs.Radiology · 2023Article
- Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Interstitial Lung Abnormalities: State of the Art.Radiology · 2021Review
- Clinical Relevance and Management of "Pre-Interstitial Lung Disease".Clinics in chest medicine · 2021Review
- Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP).European journal of radiology open · 2021Review
- Interstitial lung abnormalities - current knowledge and future directions.European clinical respiratory journal · 2021Review
- Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society.The Lancet. Respiratory medicine · 2020Article
- A case report of pulmonary amyloidosis recognized by detection of AA amyloid exclusively in alveolar macrophages.Respiratory medicine case reports · 2020Article
- Histologic Findings of Severe/Therapy-Resistant Asthma From Video-assisted Thoracoscopic Surgery Biopsies.The American journal of surgical pathology · 2017Article
- Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.International journal of chronic obstructive pulmonary diseaseReview
- Interstitial Lung Abnormalities at CT: Subtypes, Clinical Significance, and Associations with Lung Cancer.Radiographics : a review publication of the Radiological Society of North America, IncReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The prevalence of incidental nonneoplastic lung disease in patients undergoing resection for mass lesions is unknown. We determined the prevalence and characteristics of parenchymal findings in patients with lung nodules, aiming to increase awareness of findings that could potentially impact patient management. A total of 397 patients with benign or malignant mass lesions with available presurgical chest computed tomography scans resected between January 2001 and July 2015 were included. Retrospective histologic assessment of parenchymal abnormalities in at least 1 section of grossly normal lung was performed for each case by 2 pulmonary pathologists and correlated with original pathology reports, clinical history, and radiologic findings. A total of 233 women and 164 men underwent resections for carcinomas (78%) or benign nodules (22%). One hundred one (25%) patients showed parenchymal abnormalities, including 14 patients with multiple findings. The most common abnormal findings were fibrotic interstitial changes (10%), including usual interstitial pneumonia (1%), followed by granulomatous processes (8%). Other findings included aspiration (4%), intravascular thrombi (2%), Langerhans cell histiocytosis (1.5%), constrictive bronchiolitis (1%), atypical lymphoid infiltrates (1%), and amyloidosis (0.5%). Abnormalities were more likely to have been documented in the original pathology report by pulmonary pathologists (68%) than by general pathologists (15%) (P < .0001). Cases with histologic parenchymal abnormalities were more likely to show radiologic interstitial lung abnormalities than those without (16% versus 5%; P = .001). Evaluation of background lung parenchyma may yield valuable and unanticipated information in patients undergoing surgical resections for lung masses that may correlate with radiographic interstitial lung abnormalities and influence clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.