Evidence map›Paper›PMID 30657873›Full record

ArticleChemical senses2019

A Novel Olfactometer for Efficient and Flexible Odorant Delivery.

Shawn D Burton, Mia Wipfel, Michael Guo, Thomas P Eiting, Matt Wachowiak

Abstract read
In one paragraph

Article in Chemical senses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Attraction ofEcology and evolution · 2025
    Article
  6. Article
  7. Constructing an Olfactometer for Rodent Olfactory Behavior Studies.Journal of visualized experiments : JoVE · 2025
    Article
  8. Article
  9. Dense and Persistent Odor Representations in the Olfactory Bulb of Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Article
  11. Conserved neural dynamics and computations across species in olfaction.bioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Bio-protocol · 2021
    Article
  16. Article
  17. Effect of Interglomerular Inhibitory Networks on Olfactory Bulb Odor Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shawn D BurtonDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.
Mia WipfelDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Michael GuoDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Thomas P EitingDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.
Matt WachowiakDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.

Funding

Dynamics of Glomerular Coding in the Olfactory BulbR01DC006441 · NIDCD · UNIVERSITY OF UTAH · PI WACHOWIAK, DALE M · 2004 to 2018
$4.9M
Effects of sniffing dynamics on olfactory bulb processingF32DC015389 · NIDCD · UNIVERSITY OF UTAH · PI EITING, THOMAS P · 2016 to 2018
$175k
Large-scale monitoring of sensory transformations in the mammalian olfactory systemF32MH115448 · NIMH · UNIVERSITY OF UTAH · PI BURTON, SHAWN DENVER · 2017 to 2019
$106k
NIDCD NIH HHS F32 DC015389NIDCD NIH HHS R01 DC006441NIMH NIH HHS F32 MH115448
6 · The paper itself

Abstract

Understanding how sensory space maps to neural activity in the olfactory system requires efficiently and flexibly delivering numerous odorants within single experimental preparations. Such delivery is difficult with current olfactometer designs, which typically include limited numbers of stimulus channels and are subject to intertrial and interchannel contamination of odorants. Here, we present a novel olfactometer design that is easily constructed, modular, and capable of delivering an unlimited number of odorants in air with temporal precision and no detectable intertrial or interchannel contamination. The olfactometer further allows for the flexible generation of odorant mixtures and flexible timing of odorant sequences. Odorant delivery from the olfactometer is turbulent but reliable from trial to trial, supporting operant conditioning of mice in an odorant discrimination task and permitting odorants and concentrations to be mapped to neural activity with a level of precision equivalent to that obtained with a flow dilution olfactometer. This novel design thus provides several unique advantages for interrogating olfactory perception and for mapping sensory space to neural activity in the olfactory system.

Indexed as

Conditioning, OperantOlfactometrySmellAnimalsFemaleMaleMiceMice, Inbred C57BLOdorantscalcium imagingolfactionolfactory bulboperant conditioningplume

Identifiers

PMID30657873
PMCPMC6410398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.