Evidence map›Paper›PMID 30657646›Full record

Observational studyInternational forum of allergy & rhinology2019

Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis.

Quinn Orb, Abigail Pulsipher, Kristine A Smith, Shaelene Ashby, Jeremiah A Alt

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International forum of allergy & rhinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Comprehensive immunological and molecular analysis revealed inflammation-related diagnostic signatures in chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Decreased retinal nerve fiber and choroidal thickness in chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  6. Evaluation of the incidence of inflammatory and tumor pathology of nose and nasal sinus region.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Quinn OrbDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT.
Abigail PulsipherDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT.
Kristine A SmithDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-7026-5819
Shaelene AshbyDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT.
Jeremiah A AltDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT.ORCID 0000-0003-0560-5028
University of Utah · USUniversity of Manitoba · CA

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for clinical and Translational ScienceKL2TR001065 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$1.1M
NCATS NIH HHS KL2 TR001065NCATS NIH HHS KL2TR001065NCATS NIH HHS UL1 TR002538
6 · The paper itself

Abstract

backgroundLocal sinonasal inflammation resulting from altered T-cell immune signaling is a contributor to the pathogenesis of chronic rhinosinusitis (CRS). CRS patients experience negative impacts on quality of life (QOL) and suffer from comorbidities linked to systemic inflammation. However, systemic inflammatory profiling to evaluate the association between systemic inflammation and QOL in CRS has not been performed. Our objectives were to compare local and systemic inflammatory gene expression in patients with CRS to determine if systemic markers of inflammation associate with disease severity and disease-specific QOL.

methodsA prospective observational study was conducted comparing 16 patients with CRS to 10 controls. Inflammatory gene expression in the anterior ethmoid tissues and peripheral blood of patients was measured using multiplex gene expression analysis and correlated to disease severity (computed tomography and nasal endoscopy) and disease-specific QOL (22-item Sino-Nasal Outcome Test [SNOT-22] and Rhinosinusitis Disability Index) using linear regression analyses.

resultsPatients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla-dqa1, hla-dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). Soluble and local ctla4 and jak1 showed a significant positive correlation with clinical markers of disease severity and disease-specific QOL (p < 0.05).

conclusionLocal and systemic gene expression involved in T-cell immune signaling was found to be significantly altered in the blood and sinonasal tissues of patients with CRS compared to controls and significantly correlated to disease severity and QOL in patients with CRS.

Indexed as

Chronic DiseaseCTLA-4 AntigenDual-Specificity PhosphatasesEthmoid SinusFemaleGene ExpressionHLA-DQ alpha-ChainsHLA-DQ beta-ChainsHumansInflammationJanus Kinase 1MaleMiddle AgedMitogen-Activated Protein Kinase PhosphatasesQuality of LifeRhinitisCTLA-4 AntigenCTLA4 protein, humanDual-Specificity PhosphatasesDUSP4 protein, humanHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsJAK1 protein, humanJanus Kinase 1Mitogen-Activated Protein Kinase Phosphataseschronic rhinosinusitisdisease severityquality of lifesinusitisSNOT-22

Identifiers

PMID30657646
PMCPMC6491244
OpenAlexW2908731513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.