ArticleClinical and translational science2019
How to Conduct Clinical Trials in Children: A Tutorial.
Article in Clinical and translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Drug Development in Pediatric Chronic Kidney Disease: A Review of Promising Treatments, Old Challenges, and New Strategies.Paediatric drugs · 2025Review
- Application of digital engagement tools for exception from informed consent community consultation and public disclosure in the pediatric prehospital airway resuscitation trial.Resuscitation plus · 2025Article
- Requirements and special considerations for drug trials with children across six jurisdictions: 1. Clinical trial application review in the regulatory approval process.Frontiers in medicine · 2025Article
- Delta-S-Cys-Albumin as a Marker of Pediatric Biospecimen Integrity.Biopreservation and biobanking · 2024Article
- Monitoring Activity and Gait in Children (MAGIC) using digital health technologies.Pediatric research · 2024Article
- Facilitators and barriers to adolescent participation in a TB clinical trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024Article
- Recent landscape and trends for industry-sponsored pediatric clinical trials in China from 2013 to 2022.Pediatric investigation · 2024Article
- Using Patient Perspectives to Inform Better Clinical Trial Design and Conduct: Current Trends and Future Directions.Pharmaceutical medicine · 2023Review
- Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials.Frontiers in pediatrics · 2023Review
- Editorial: Methods and protocols in obstetric and pediatric pharmacology: 2022.Frontiers in pharmacology · 2023Article
- Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.Clinical and translational science · 2022Article
- Design and conduct considerations for studies in patients with impaired renal function.Clinical and translational science · 2021Article
- Challenges in conducting paediatric trials with off-patent drugs.Contemporary clinical trials communications · 2021Article
- Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective.Clinical and translational science · 2021Article
- Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity.Obesity (Silver Spring, Md.) · 2020Article
- Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities.Paediatric drugs · 2020Review
- Involve Children and Parents in Clinical Studies.Clinical and translational science · 2020Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a growing interest in, and commitment to, implementing pediatric clinical trials, approximately one in every five trials in children fails because of inappropriate study design, suboptimal experiment planning, or inadequate participant enrollment. This tutorial, presented from the perspectives of seasoned pediatric investigators, an experienced research coordinator, and an established pediatric clinical trials network, is designed to provide practical guidance for successfully implementing pediatric clinical trials at an academic center or another comparable institution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.