ArticleVeterinary medicine and science2019
New serological platform for detecting antibodies against Mycobacterium tuberculosis complex in European badgers.
Article in Veterinary medicine and science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Diagnosis of tuberculosis in wildlife: a systematic review.Veterinary research · 2021Pooled it
- A unique dataset of immunological and bacteriological test results from experimental infection of European badgersData in brief · 2026Article
- Proteome microarray-guided identification of mycobacterial antigens and ELISA-based peptide mapping for improved serological detection ofJournal of clinical microbiology · 2026Article
- Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model.Veterinary research · 2024Article
- Genomic comparison betweenFrontiers in veterinary science · 2024Article
- Efficacy of heat-inactivatedHeliyon · 2023Article
- A humoral diagnostic test outperforms cellular tests in a farm with a latent tuberculosis outbreak caused by a newFrontiers in veterinary science · 2023Article
- Evidence, Challenges, and Knowledge Gaps Regarding Latent Tuberculosis in Animals.Microorganisms · 2022Review
- Untargeted metabolomic analysis of thoracic blood from badgers indicate changes linked to infection with bovine tuberculosis (Mycobacterium bovis): a pilot study.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Metabotyping the Welsh population of badgers based on thoracic fluid.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Review of Methods Used for Diagnosing Tuberculosis in Captive and Free-Ranging Non-Bovid Species (2012-2020).Pathogens (Basel, Switzerland) · 2021Review
- Spatial and Temporal Distribution ofAnimals : an open access journal from MDPI · 2021Article
- Protective Effect of Oral BCG and InactivatedFrontiers in veterinary science · 2020Article
- Evaluation of P22 Antigenic Complex for the Immuno-Diagnosis of Tuberculosis in BCG Vaccinated and Unvaccinated Goats.Frontiers in veterinary science · 2020Article
- Tuberculosis Epidemiology and Badger (Pathogens (Basel, Switzerland) · 2019Article
- Purification and Characterisation of Badger IgA and Its Detection in the Context of Tuberculosis.Veterinary sciences · 2019Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
European badgers (Meles meles) have been identified as wildlife reservoirs for Mycobacterium bovis in the UK and Ireland, and may also have a role in the epidemiology of animal tuberculosis in other European regions. Thus, detection of M. bovis-infected badgers may be required for the purposes of surveillance and monitoring of disease levels in infected populations. Current serological assays to detect M. bovis infection in live badgers, while rapid and inexpensive, show limited diagnostic sensitivity. Here we describe and evaluate new ELISA platforms for the recognition of the P22 multiprotein complex derived from the purified protein derivative (PPD) of M. bovis. The recognition of IgG against P22 multiprotein complex derived from PPD-B was tested by ELISA in the serum of badgers from the UK, Ireland and Spain. TB infection in the badgers was indicated by the presence of M. bovis in tissues by culture and histology at post-mortem examination and TB-free status was established by repeated negativity in the interferon γ release assay (IGRA). In experimentally infected badgers, humoral antibody responses against P22 developed within 45 days post-infection. The ELISA tests showed estimated sensitivity levels of 74-82% in experimentally and naturally infected badgers with specificities ranging from 75% to 100% depending on the badger population tested. The P22 multi-antigen based ELISAs provide a sensitive and specific test platform for improved tuberculosis surveillance in badgers.
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