Evidence map›Paper›PMID 30656594›Full record

ArticleNeurochemical research2019

Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats.

Mohadeseh Ghalandari-Shamami, Shahla Nourizade, Behpour Yousefi, Abbas Ali Vafaei, Roghayeh Pakdel, Ali Rashidy-Pour

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In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohadeseh Ghalandari-ShamamiStudent Research Committee, Semnan University of Medical Sciences, Semnan, Iran.
Shahla NourizadeLaboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran.
Behpour YousefiDepartment of Anatomical Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Abbas Ali VafaeiLaboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran.
Roghayeh PakdelLaboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran.
Ali Rashidy-PourLaboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran. Rashidy-Pour@semums.ac.ir.
Semnan University of Medical Sciences · IRSemnan University · IR

Funding

Semnan University of Medical Science 984
6 · The paper itself

Abstract

Increasing evidence suggests that exposure to chronic stress during adolescent period may lead to behavioral and neuronal morphology deficits in adulthood. This study examined whether crocin, the main active saffron constituent, and voluntary exercise, alone or combined, could prevent the detrimental influences of chronic restraint stress during adolescent (postnatal days, PND, 30-40) on behavioral and morphological deficits in adult (PND60) male rats. Results showed that plasma corticosterone levels increased at PND40, but not PND60 in stressed rats. Moreover, stressed rats demonstrated enhanced anxiety levels and depression like behaviors in adulthood. These behavioral abnormalities were accompanied by a decline in apical dendritic length in both infralimbic and prelimbic regions and dendritic branches in infralimbic region of the prefrontal cortex. Treatment with crocin, exposure to wheel running activity, and the combined interventions alleviated both behavioral and morphological deficits induced by adolescent stress. Moreover, these treatments exerted positive neuronal morphological effects in the prefrontal cortex in non-stressed animals. Our findings provide important evidences that exercise as a non-pharmacological intervention and crocin treatment during pre-pubertal period can protect against adolescent stress induced behavioral and morphological abnormalities in adulthood.

Indexed as

AnimalsAnxietyCarotenoidsCombined Modality TherapyCorticosteroneDendritesDepressionMalePhysical Conditioning, AnimalPrefrontal CortexRatsRats, WistarRestraint, PhysicalStress, PsychologicalTreatment OutcomeCarotenoidsCorticosteronecrocinAdolescent stressAnxietyCrocinDendritic remodelingDepressionPrefrontal cortexRunning wheel exercise

Identifiers

PMID30656594
OpenAlexW2910702611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.