ArticleJournal of cancer research and clinical oncology2019
Effects of metabolic syndrome on the prevalence of prostate cancer: historical cohort study using the national health insurance service database.
Article in Journal of cancer research and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Association between benign prostate hyperplasia and metabolic syndrome in men under 60 years old: a meta-analysis.The Journal of international medical research · 2019Pooled it
- Effectiveness of a Nurse-Led Mobile-Based Health Coaching Program for Patients With Prostate Cancer at High Risk of Metabolic Syndrome: Randomized Waitlist Controlled Trial.JMIR mHealth and uHealth · 2024Trial
- Associations between metabolic obesity phenotypes and prostate cancer in the U.S. population: a cross-sectional study.Translational andrology and urology · 2025Article
- Prostate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data.Discover oncology · 2025Article
- Machine learning algorithms that predict the risk of prostate cancer based on metabolic syndrome and sociodemographic characteristics: a prospective cohort study.BMC public health · 2024Article
- Transitions in metabolic syndrome and metabolic obesity status over time and risk of urologic cancer: A prospective cohort study.PloS one · 2024Article
- Association of metabolic syndrome and its components with the risk of urologic cancers: a prospective cohort study.BMC urology · 2023Article
- Association between metabolic syndrome and gastric cancer risk: results from the Health Examinees Study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.Journal of obesity & metabolic syndrome · 2023Review
- Association between atherogenic lipids and GnRH agonists for prostate cancer in men with T2DM: a nationwide, population-based cohort study in Sweden.British journal of cancer · 2023Article
- Association between life-style, metabolic syndrome and lower urinary tract symptoms and its impact on quality of life in men ≥ 40 years.Scientific reports · 2022Article
- Different effect of obesity and metabolic syndrome on prostate cancer by age group.American journal of cancer research · 2022Article
- The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database.International journal of clinical oncology · 2021Article
- Lifestyles, health habits, and prostate cancer.Journal of cancer research and clinical oncology · 2020Article
- PCaLiStDB: a lifestyle database for precision prevention of prostate cancer.Database : the journal of biological databases and curation · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo estimate the effect of metabolic syndrome (MetS) on the prevalence of prostate cancer using a large retrospective cohort with a 5-year follow-up duration.
methodsNational Health Insurance Service health checkup cohort was used for the study. In total, 130,342 men included in the health checkup cohort in 2009 were divided into two groups according to the presence of prostate cancer. The prevalence of prostate cancer from 2009 to 2013 was cumulatively calculated from 2003. A generalized estimating equation was used to assess the effect of MetS and its component on the prevalence of prostate cancer after adjusting for other variables.
resultsProstate cancer was present in 2369 men (1.8%) in 2009. The prevalence of prostate cancer was significantly higher in patients with MetS than in those without MetS throughout the entire follow-up duration. Multivariable analysis showed that in addition to year at evaluation and age, the presence of MetS was associated with an increased prevalence of prostate cancer. Alcohol consumption and smoking levels were negatively associated with the prevalence of prostate cancer. Among MetS components, decreased high density lipoprotein (HDL)-cholesterolemia and central obesity were associated with an increased prevalence of prostate cancer after adjusting for other variables.
conclusionMetS and its components, especially decreased HDL-cholesterol levels and central obesity, were related to the increased prevalence of prostate cancer. Preventing MetS, maintaining high HDL-cholesterol level, and maintaining low waist circumference might be useful ways for decreasing the prevalence of prostate cancer.
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