ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019
Tissue healing following segmental meniscal allograft transplantation: a pilot study.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- A Novel Approach to Segmental Meniscal Repair Improves Ultimate Strength and Resistance to Cyclic Fatigue.Orthopaedic journal of sports medicine · 2026Article
- Partial meniscus allograft transplantation preserving the recipient's anterior root: a comparative study in a rabbit model.European journal of medical research · 2025Article
- A new preclinical sheep model of medial meniscus anterior root repair: Part 2-Surgical strategy, technical considerations, pearls and pitfalls.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- A new preclinical sheep model of medial meniscus anterior root repair: Part 1-Quantitative morphology and relationships to adjacent structures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Treatment of Failed Lateral Meniscal Oblique Radial Tear Repair With Segmental Allograft Meniscus Transplantation.Arthroscopy techniques · 2025Article
- Meniscus Size Differs Between Patient and Donor Populations for Meniscus Allograft Transplantation.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Segmental Medial Meniscus Transplantation in Combination With BMAC (Bone Marrow Aspirate Concentrate) Injection to Improve Healing and Prevent Extrusion.Arthroscopy techniques · 2022Article
- Study on feasibility of the partial meniscal allograft transplantation.Clinical and translational medicine · 2022Article
- Arthroscopic Segmental Medial Meniscus Allograft Transplant Using Three Fixation Techniques.Arthroscopy techniques · 2021Article
- Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThis in vivo histological study using an ovine model evaluated the 90-day healing of unilateral segmental meniscal allograft transplantation.
methodsFresh-frozen medial menisci were transplanted to replace the right medial meniscus of six female sheep. Tissue healing was evaluated using semi-quantitative, descriptive methods. Formalin-fixed meniscal, distal femur and proximal tibia tissues were evaluated using Rodeo (cellularity/collagen), Ishida (reparative bonding), Collagen I IHC (collagen I), and Mankin (cartilage organization) scores at the medial femoral condyle (MFC) and medial tibial plateau (MTP). Meniscocapsular evaluations were performed at the: (a) peripheral junction; (b) posterior sector-native meniscus junction; (c) anterior sector-native meniscus junction; (d) posterior horn internal control; and (e) anterior horn internal control.
resultsThree animals were euthanized at 39 ± 2.6 days post-surgery because of their knee condition. These animals had moderate Rodeo scores, low Ishida scores, and high Collagen I staining scores indicating moderately high fibrocartilaginous changes, mild or minimal healing and high collagen I content. Cartilage scores were low in the MFC and moderately high in the MTP, indicating mild MFC cartilage changes and moderately high MTP cartilage changes. Full-term (90 day) euthanized animals (n = 3) displayed improving Rodeo scores with mean scores of 3.3 and 3.6 at junctions (B) and (C), respectively. Ishida scores displayed similar improvements at all sectors. Collagen I staining revealed strong (grade 5) levels in all sections, with mean collagen I scores of 5, 5 and 4 for the peripheral (A), posterior (B) and anterior (C) junctions, respectively. Improved healing was observed at each segmental meniscus sector in terminally euthanized animals.
conclusionsSegmental meniscal allograft transplantation displayed partial healing to remnant meniscal tissue. Further study is needed to better delineate the time needed for complete healing and the joint-loading progression that may enhance it.
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