Evidence map›Paper›PMID 30656360›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2019

Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression.

Samira Khabbazi, Mohammadhossein Hassanshahi, Alireza Hassanshahi, Yaser Peymanfar, Yu-Wen Su, Cory J Xian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  9. Local anesthetics elicit immune-dependent anticancer effects.Journal for immunotherapy of cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Samira Khabbazi *School of Medical Science, The South Australian Health and Medical Research Institute, The University of Adelaide, Adelaide, SA, 5001, Australia.
Mohammadhossein Hassanshahi *School of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.
Alireza HassanshahiDepartment of Genetics, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran.
Yaser PeymanfarSchool of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.
Yu-Wen SuSchool of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.
Cory J XianSchool of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. cory.xian@unisa.edu.au.
University of South Australia · AUIslamic Azad University of Shahrekord · IRSouth Australian Health and Medical Research Institute · AU

Funding

National Health and Medical Research Council 0508046National Health and Medical Research Council 0508047National Health and Medical Research Council 1042105
6 · The paper itself

Abstract

Opioids are widely administered to alleviate pain, including chronic pain in advanced cancer patients. Among opioids, morphine is one of the most clinically effective drugs for the palliative management of severe pain. In the last few decades, there has been a debate around the possible influence of opioids such as morphine on tumour growth and metastasis. Whilst several in vitro and in vivo studies suggest the possible modulatory effects of morphine on tumour cells, little is known about the impact of this analgesic drug on other mediators such as matrix metalloproteinases (MMPs) that play a key role in the control of cancer cell invasion and metastasis. MMP-9 has been considered as one of the principal mediators in regulation of not only the initial steps of cancer but during the invasion and spreading of cancer cells to distant organs. Herein, current studies regarding the direct and indirect effects of morphine on regulation of MMP-9 production are discussed. In addition, drawing from previous in vivo and in vitro studies on morphine action in regulating MMP-9 production, the potential roles of several underlying factors are summarised, including nuclear factor kappa-B and intracellular molecules such as nitric oxide.

Indexed as

Analgesics, OpioidAnimalsDisease ProgressionHumansMatrix Metalloproteinase 9MorphineNeoplasmsNF-kappa BNitric OxideAnalgesics, OpioidMatrix Metalloproteinase 9MorphineNF-kappa BNitric OxideMatrix metalloproteinasesMMP-9MorphineNF-κBNitric oxideOpioids

Identifiers

PMID30656360
OpenAlexW2910017606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.