ArticleContemporary clinical trials communications2019
Digital recruitment and enrollment in a remote nationwide trial of screening for undiagnosed atrial fibrillation: Lessons from the randomized, controlled mSToPS trial.
Article in Contemporary clinical trials communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A systematic review of methods used to conduct decentralised clinical trials.British journal of clinical pharmacology · 2022Pooled it
- Email-Based Recruitment Into the Health eHeart Study: Cohort Analysis of Invited Eligible Patients.Journal of medical Internet research · 2023Trial
- Recruiting for a Randomized Clinical Trial for Late-Life Depression During COVID-19: Outcomes of Provider Referrals Versus Facebook Self-Referrals.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Trial
- Trial
- Design and Performance of an Email-Based Patient Recruitment Campaign in Primary Care Research: Formative Secondary Analysis.JMIR human factors · 2026Article
- Recruitment rate comparison between a virtual tele-research cohort and a traditional centre-based cohort in idiopathic inflammatory myopathy.Rheumatology (Oxford, England) · 2025Observational
- Internet-based enrollment of a myositis patient cohort-a national experience.Clinical rheumatology · 2024Observational
- Non-Invasive Biosensing for Healthcare Using Artificial Intelligence: A Semi-Systematic Review.Biosensors · 2024Review
- Narrative review of telemedicine applications in decentralized research.Journal of clinical and translational science · 2024Review
- Leveraging digital tools to enhance diversity and inclusion in clinical trial recruitment.Frontiers in public health · 2024Article
- Article
- Interventions to improve access to clinical trials in urologic oncology.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023Article
- Can learnings from the COVID-19 pandemic improve trial conduct post-pandemic? A case study of strategies used by the DISC trial.Research methods in medicine & health sciences · 2023Article
- A qualitative exploration of advantages and disadvantages to using technology in the process of randomised controlled trial recruitment.HRB open research · 2023Article
- Enrollment and Retention of Participants in Remote Digital Health Studies: Scoping Review and Framework Proposal.Journal of medical Internet research · 2022Article
- Patient Onboarding and Engagement to Build a Digital Study After Enrollment in a Clinical Trial (TAILOR-PCI Digital Study): Intervention Study.JMIR formative research · 2022Article
- Article
- Demographic Imbalances Resulting From the Bring-Your-Own-Device Study Design.JMIR mHealth and uHealth · 2022Article
- Outreach to new mothers through direct mail and email: recruitment in the Early Check research study.Clinical and translational science · 2021Article
- Large-scale screening studies for atrial fibrillation - is it worth the effort?Journal of internal medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe advent of large databases, wearable technology, and novel communications methods has the potential to expand the pool of candidate research participants and offer them the flexibility and convenience of participating in remote research. However, reports of their effectiveness are sparse. We assessed the use of various forms of outreach within a nationwide randomized clinical trial being conducted entirely by remote means.
methodsCandidate participants at possibly higher risk for atrial fibrillation were identified by means of a large insurance claims database and invited to participate in the study by their insurance provider. Enrolled participants were randomly assigned to one of two groups testing a wearable sensor device for detection of the arrhythmia.
resultsOver 10 months, the various outreach methods used resulted in enrollment of 2659 participants meeting eligibility criteria. Starting with a baseline enrollment rate of 0.8% in response to an email invitation, the recruitment campaign was iteratively optimized to ultimately include website changes and the use of a five-step outreach process (three short, personalized emails and two direct mailers) that highlighted the appeal of new technology used in the study, resulting in an enrollment rate of 9.4%. Messaging that highlighted access to new technology outperformed both appeals to altruism and appeals that highlighted accessing personal health information.
conclusionsTargeted outreach, enrollment, and management of large remote clinical trials is feasible and can be improved with an iterative approach, although more work is needed to learn how to best recruit and retain potential research participants.
trial registrationClinicaltrials.govNCT02506244. Registered 23 July 2015.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.