ArticleAnnals of clinical and translational neurology2019
Essential tremor severity and anatomical changes in brain areas controlling movement sequencing.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review.Cerebellum (London, England) · 2022Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Machine Learning Aided Kinematic Profiling of Reaching Movements Separates Spinocerebellar Ataxia type 12 and Essential Tremor.Cerebellum (London, England) · 2026Article
- Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates.Neuroimage. Reports · 2025Article
- Article
- Associations Between Cognitive Profiles and Balance in Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Changes in glucose metabolism in essential tremor: within and beyond the cerebello-thalamo-cortical circuit.Brain communications · 2025Article
- Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.Scientific reports · 2024Article
- Structural brain differences in essential tremor and Parkinson's disease deep brain stimulation patients.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Observational
- Brain microstructural changes in essential tremor patients and correlations with clinical characteristics: a diffusion kurtosis imaging study.Journal of neurology · 2023Article
- Reproducibility of cerebellar involvement as quantified by consensus structural MRI biomarkers in advanced essential tremor.Scientific reports · 2023Article
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling.NeuroImage. Clinical · 2023Article
- Evaluation of Cerebral Volume Changes in Patients with Tremor Treated by MRgFUS Thalamotomy.Life (Basel, Switzerland) · 2022Article
- Article
- Essential tremor impairs the ability to suppress involuntary action impulses.Experimental brain research · 2022Article
- Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.Network neuroscience (Cambridge, Mass.) · 2022Article
- Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients.Journal of neurology · 2022Observational
- Topologically Disrupted Gray Matter Networks in Drug-Naïve Essential Tremor Patients With Poor Sleep Quality.Frontiers in neurology · 2022Article
- Assessment of movement disorders using wearable sensors during upper limb tasks: A scoping review.Frontiers in robotics and AI · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Objective: Although the cerebello-thalamo-cortical network has often been suggested to be of importance in the pathogenesis of essential tremor (ET), the origins of tremorgenic activity in this disease are not fully understood. We used a combination of cortical thickness imaging and neurophysiological studies to analyze whether the severity of tremor was associated with anatomical changes in the brain in ET patients Methods: Magnetic resonance imaging (MRI) and a neurophysiological assessment were performed in 13 nondemented ET patients. High field structural brain MRI images acquired in a 3T scanner and analyses of cortical thickness and surface were carried out. Cortical reconstruction and volumetric segmentation was performed with the FreeSurfer image analysis software. We used high-density surface electromyography (hdEMG) and inertial measurement units (IMUs) to quantify the tremor severity in upper extrimities of patients. In particular, advanced computer tool was used to reliably identify discharge patterns of individual motor units from surface hdEMG and quantify motor unit synchronization. Results: We found significant association between increased motor unit synchronization (i.e., more severe tremor) and cortical changes (i.e., atrophy) in widespread cerebral cortical areas, including the left medial orbitofrontal cortex, left isthmus of the cingulate gyrus, right paracentral lobule, right lingual gyrus, as well as reduced left supramarginal gyrus (inferior parietal cortex), right isthmus of the cingulate gyrus, left thalamus, and left amygdala volumes. Interpretation: Given that most of these brain areas are involved in controlling movement sequencing, ET tremor could be the result of an involuntary activation of a program of motor behavior used in the genesis of voluntary repetitive movements.
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Registered trials
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