Observational studyAnnals of clinical and translational neurology2019
Sensorimotor plasticity after spinal cord injury: a longitudinal and translational study.
Observational study in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcutaneous spinal cord stimulation for motor function and functional independence in patients with spinal cord injury: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Article
- AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury.Communications biology · 2025Article
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery.Communications medicine · 2025Article
- Spinal cord lesion MRI and behavioral outcomes in a miniature pig model of spinal cord injury: exploring preclinical potential through an ad hoc comparison with human SCI.Spinal cord series and cases · 2024Article
- Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.Annals of clinical and translational neurology · 2023Article
- Primary motor hand area corticospinal excitability indicates overall functional recovery after spinal cord injury.Frontiers in neurology · 2023Article
- Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus.Frontiers in rehabilitation sciences · 2023Article
- M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury.Neural regeneration research · 2022Article
- Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review.Journal of clinical medicine · 2022Review
- Porcine Model of Spinal Cord Injury: A Systematic Review.Neurotrauma reports · 2022Article
- Cortical layer-specific modulation of neuronal activity after sensory deprivation due to spinal cord injury.The Journal of physiology · 2021Article
- Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury.The Journal of international medical research · 2020Article
- Effects of Growth Hormone Treatment and Rehabilitation in Incomplete Chronic Traumatic Spinal Cord Injury: Insight from Proteome Analysis.Journal of personalized medicine · 2020Article
- Application of electrophysiological measures in spinal cord injury clinical trials: a narrative review.Spinal cord · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The objective was to track and compare the progression of neuroplastic changes in a large animal model and humans with spinal cord injury. Methods: A total of 37 individuals with acute traumatic spinal cord injury were followed over time (1, 3, 6, and 12 months post-injury) with repeated neurophysiological assessments. Somatosensory and motor evoked potentials were recorded in the upper extremities above the level of injury. In a reverse-translational approach, similar neurophysiological techniques were examined in a porcine model of thoracic spinal cord injury. Twelve Yucatan mini-pigs underwent a contusive spinal cord injury at T10 and tracked with somatosensory and motor evoked potentials assessments in the fore- and hind limbs pre- (baseline, post-laminectomy) and post-injury (10 min, 3 h, 12 weeks). Results: In both humans and pigs, the sensory responses in the cranial coordinates of upper extremities/forelimbs progressively increased from immediately post-injury to later time points. Motor responses in the forelimbs increased immediately after experimental injury in pigs, remaining elevated at 12 weeks. In humans, motor evoked potentials were significantly higher at 1-month (and remained so at 1 year) compared to normative values. Conclusions: Despite notable differences between experimental models and the human condition, the brain's response to spinal cord injury is remarkably similar between humans and pigs. Our findings further underscore the utility of this large animal model in translational spinal cord injury research.
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