ArticleAnnals of clinical and translational neurology2019
Association between cirrhosis and aneurysmal subarachnoid hemorrhage.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Coagulation Abnormalities in Liver Cirrhosis: Diagnostic and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2026Review
- Risk of Cerebral Aneurysm Rupture After Liver Transplantation: Development and Validation of a Hemorrhagic Stroke Scoring Model.Journal of Korean medical science · 2024Article
- Review
- Rupture Risk of Intracranial Aneurysm and Prediction of Hemorrhagic Stroke after Liver Transplant.Brain sciences · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Objective: Cirrhosis has been associated with nontraumatic subarachnoid hemorrhage (SAH). We sought to evaluate the specific association between cirrhosis and aneurysmal SAH. Methods: We performed a retrospective cohort study using a sample of Medicare claims data from 2008 to 2015. Cirrhosis was defined using a validated Results: We identified 10,658 (0.6%) patients with cirrhosis from among the 1,778,604 beneficiaries in our sample. The mean age of patients with cirrhosis was 73.5 (±7.8) years, and 48% were female. Over a mean of 4.7 (±2.1) years of follow-up, 4,272 patients were hospitalized with aneurysmal SAH. The annual incidence of aneurysmal SAH in patients with cirrhosis was 0.12% (95% confidence interval [CI], 0.08-0.17%) compared to 0.05% (95% CI, 0.05-0.05%) in patients without cirrhosis. In the adjusted model, cirrhosis was independently associated with aneurysmal SAH (hazard ratio, 2.2; 95% confidence interval, 1.5-3.4). Interpretation: Cirrhosis was independently associated with an increased risk of aneurysmal SAH among older individuals. Confirmation of these findings may yield opportunities for risk stratification and prevention.
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