ArticlePeerJ2019
Identification and characterization of capsule depolymerase Dpo48 from
Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed, 57 citations in OpenAlex.
- A novel Acinetobacter phage reveals altered virulence traits in phage-resistant strains.Virulence · 2026Article
- Isolation and characterization of a novel Schitoviridae phage VipHU7 that infects Vibrio parahaemolyticus.Archives of virology · 2026Article
- One-Step Immobilized Phage Depolymerase Coatings for Catheter-Related Bloodstream Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A comprehensive analysis of the kinetics of infection of lytic bacteriophages specific to the ESKAPE and critical pathogens.World journal of microbiology & biotechnology · 2026Review
- Mining a vibriophage depolymerase for enhanced pathogen control in aquaculture.Applied and environmental microbiology · 2026Article
- Unraveling the Coevolutionary Dynamics of Phage and Bacterial Protein Warfare Occurring in the Drains of Beef-Processing Plants.Microorganisms · 2026Article
- PDP-Miner: an AI/ML tool to detect prophage tail proteins with depolymerase domains across thousands of bacterial genomes.Bioinformatics (Oxford, England) · 2025Article
- Antibiotic-resistant Acinetobacter baumannii can be killed by a combination of bacteriophages and complement.Medical microbiology and immunology · 2025Article
- The virulent bacteriophage Henu8 as an antimicrobial synergist againstMicrobiology spectrum · 2025Article
- Genomic and Functional Characterization of Novel Phages Targeting Multidrug-ResistantInternational journal of molecular sciences · 2025Article
- Bacteriophage Indie resensitizes multidrug-resistant Acinetobacter baumannii to antibiotics in vitro.Scientific reports · 2025Article
- Characterization of a novel lytic phage vB_AbaM_AB4P2 encoding depolymerase and its application in eliminating biofilms formed by Acinetobacter baumannii.BMC microbiology · 2025Article
- Identification and functional characterization of a novelFrontiers in cellular and infection microbiology · 2025Article
- Identification of multi-drug resistantFrontiers in microbiology · 2025Article
- Lytic Capsule-SpecificViruses · 2024Article
- Two novel phages, Klebsiella phage GADU21 and Escherichia phage GADU22, from the urine samples of patients with urinary tract infection.Virus genes · 2024Article
- Phage-encoded depolymerases as a strategy for combating multidrug-resistantFrontiers in cellular and infection microbiology · 2024Review
- Identification and characterization of the capsule depolymerase Dpo27 from phage IME-Ap7 specific toFrontiers in cellular and infection microbiology · 2024Article
- Functional domains ofFrontiers in microbiology · 2024Article
- Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emergence of multidrug- or extensively drug-resistant
methodsA bacteriophage was isolated from hospital sewage using an extensively drug-resistant
resultsPhage IME200 yielded clear plaques surrounded by enlarged halos, with polysaccharide depolymerase activity against the host bacterium. A tail fiber protein with a Pectate_lyase_3 domain was identified as Dpo48 and characterized . Dpo48 was found to degrade the capsule polysaccharide of the bacterial surface, as revealed by Alcian blue staining. Dpo48 manifested stable activity over a broad range of pH (5.0-9.0) and temperatures (20-70 °C). Results from
conclusionsPhage-encoded capsule depolymerases may become promising antivirulence agents for preventing and controlling
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.