Evidence map›Paper›PMID 30655788›Full record

ArticleOncology letters2019

Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report.

Guido Giordano, Nunzio Olivieri, Mario Rosario D'Andrea, Tania Di Raimo, Erminia Manfrin, Andrea Remo, Massimo Pancione, Matteo Brunelli, Elena De Santis, Giulia Coppola and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Guido GiordanoOncology Division IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, I-71013 Foggia, Italy.
Nunzio OlivieriBiology Department, Federico II University of Naples, I-80134 Naples, Italy.
Mario Rosario D'AndreaMedical Oncology Unit, San Filippo Neri Hospital, I-00135 Rome, Italy.
Tania Di RaimoMedical Oncology Unit, San Filippo Neri Hospital, I-00135 Rome, Italy.
Erminia ManfrinDepartment of Diagnostics and Public Health-Section of Pathology, University and Hospital Trust of Verona, I-37134 Verona, Italy.
Andrea RemoPathology Unit, Mater Salutis Hospital, ULSS9, Legnago, I-37045 Verona, Italy.
Massimo PancioneDepartment of Sciences and Technologies, University of Sannio, I-82100 Benevento, Italy.
Matteo BrunelliDepartment of Diagnostics and Public Health-Section of Pathology, University and Hospital Trust of Verona, I-37134 Verona, Italy.
Elena De SantisDepartment of Human Anatomy, Sapienza University of Rome, I-00185 Rome, Italy.
Giulia CoppolaDepartment of Human Anatomy, Sapienza University of Rome, I-00185 Rome, Italy.
Aldo ScarpaDepartment of Diagnostics and Public Health-Section of Pathology, University and Hospital Trust of Verona, I-37134 Verona, Italy.
Luigi CoppolaUOC of Pathologic Anatomy, San Filippo Neri Hospital, I-00135 Rome, Italy.
Pietro ParcesepeDepartment of Diagnostics and Public Health-Section of Pathology, University and Hospital Trust of Verona, I-37134 Verona, Italy.
University of Verona · ITOspedale San Filippo Neri · ITSapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Naples Federico II · ITUniversity of Sannio · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The eye is a rare site for disseminated malignancies; nevertheless, several tumors may metastasize to ocular structures. Few cases of urothelial and bladder cancer with eye involvement have been described in the literature thus far. The rarity of metastatic ocular localization implies an accurate differential diagnosis among the possible primary tumor sites. However, a specific diagnostic algorithm is not currently available, nor a defined therapeutic approach. Eye metastases are associated with advanced disease and poor prognosis. Physicians should be made aware of the possibility of eye involvement in patients with a past medical history of urothelial bladder cancer associated with ocular symptoms. The present case reports discusses the first documented case, to the best of our knowledge, of an urothelial bladder cancer metastasizing to the retro bulbar region that infiltrates the lacrimal gland. Furthermore, the report provides a systematic qualitative review of the current literature on eye metastases from urothelial bladder cancer using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Indexed as

bladdereyeGATA3ocular metastasesurothelial carcinoma

Identifiers

PMID30655788
PMCPMC6313172
OpenAlexW2895836067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.