ArticleReproductive medicine and biology2019
The timing of cumulus cell removal for intracytoplasmic sperm injection influences the capability of embryonic development.
Article in Reproductive medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Cumulus cell antioxidant system is modulated by patients' clinical characteristics and correlates with embryo development.Journal of assisted reproduction and genetics · 2022Pooled it
- Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- What is the optimal timing of intracytoplasmic sperm injection (ICSI) after EGG retrieval? A randomized controlled trial.Journal of assisted reproduction and genetics · 2021Trial
- Examining the impact of denudation and ICSI timing on embryological and clinical outcomes in oocyte donation cycles.Journal of assisted reproduction and genetics · 2026Article
- The clinical value of short-term insemination: a retrospective analysis of 3496 patients.BMC pregnancy and childbirth · 2025Article
- Non-Male Factor Only-ICSI Can Overcome Oocyte Factor in PCOS Patients.Journal of clinical medicine · 2025Article
- Effect of the time interval between denudation and ICSI on fresh embryo transfer reproductive outcomes: a retrospective study.Frontiers in endocrinology · 2024Article
- A 3-4 h oocyte retrieval-ICSI interval optimizes clinical outcomes for women over 40 years.Scientific reports · 2023Article
- Personalization of IVF-ICSI workflow based on patient characteristics improves IVF laboratory outcomes and embryo ploidy by PGT-A.Journal of ovarian research · 2022Article
- Re-denudation of residual cumulus cells on day 3 increases the accuracy of cell-free DNA detection in spent embryo culture medium.Journal of assisted reproduction and genetics · 2022Article
- A novel embryo quality scoring system to compare groups of embryos at different developmental stages.Journal of assisted reproduction and genetics · 2021Article
- Performing ICSI within 4 hours after denudation optimizes clinical outcomes in ICSI cycles.Reproductive biology and endocrinology : RB&E · 2020Article
- The timing of cumulus cell removal for intracytoplasmic sperm injection influences the capability of embryonic development.Reproductive medicine and biology · 2019Article
- Two-six Hours is the Optimal Timing of Intracytoplasmic Sperm Injection After Oocyte Pickup: Single-centre 10 Years Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine whether the presence of intact cumulus cells during the preincubation period for ICSI should be considered as a critical factor in fertilization and embryonic development.
methodsThe cohort of this prospective randomized study was limited to infertile women younger than 39 years of age who underwent controlled ovarian stimulation for ICSI between October 2013 and May 2015 and whose embryos were to be incubated until day 5. Women with estradiol levels of <2000 pmol/L on the day of HCG injection were excluded. Cumulus cells were removed immediately after OPU in Group A and at 120 minutes after OPU in Group B. ICSI was performed with all mature oocytes, and fertilized oocytes were cultured to the blastocyst stage. Maturation, fertilization, blastocyst, good quality blastocyst, pregnancy, live birth, and miscarriage rates were compared.
resultsThere were no significant differences in maturation, fertilization, blastocyst, pregnancy, live birth, or miscarriage rates between Groups A and B. However, the percentage of good quality blastocysts was significantly higher in Group B than Group A (52.0% vs 33.1%).
conclusionsIntact cumulus cells should be maintained during the preincubation period, as they are important to embryonic development after fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.