Evidence map›Paper›PMID 30655696›Full record

ArticleCancer management and research2019

A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma.

Huifei Zheng, Tengfei Chen, Chang Li, Chun Xu, Cheng Ding, Jun Chen, Sheng Ju, Zhiwei Zhang, Zhipan Liang, Zihan Cui and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. The roles and mechanisms of circular RNAs related to mTOR in cancers.Journal of clinical laboratory analysis · 2022
    Review
  7. Article
  8. Circular RNAs Involved in the Regulation of the Age-Related Pathways.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Circular RNAs in hepatocellular carcinoma: Recent advances.World journal of gastrointestinal oncology · 2022
    Review
  11. Review
  12. Circular RNA in cancer development and immune regulation.Journal of cellular and molecular medicine · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Huifei ZhengNational Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Tengfei ChenDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Chang LiDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Chun XuDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Cheng DingDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Jun ChenDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Sheng JuDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Zhiwei ZhangDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Zhipan LiangDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Zihan CuiDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Jun ZhaoDepartment of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China, junzhao@suda.edu.cn.
Soochow University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost recently, circular RNAs (circRNAs) were considered playing regulatory roles in tumor initiation and development. The specific function of circRNAs in hepatocellular carcinoma (HCC) remains unknown. This study was designed to detect specific roles of a circRNA hsa_circ_0079299 in HCC.

methodsThe expression of hsa_circ_0079299 in HCC and tumor cell lines was detected using quantitative PCR (qPCR). Cell proliferation, migration, cell cycle and apoptosis after overexpression of the circRNA were measured using cell counting kit-8 (CCK8) assay, colony formation, 5-ethynyl-2'-deoxyuridine (EdU) assay, wound healing assay, transwell culture system and flow cytometry. Western blotting assay detected the protein expression of PI3K/AKT/mTOR signaling pathway and cyclin B1 (CCNB1). Overexpression of the circRNA in vivo was measured by nude mice tumorigenesis.

resultsThe expression of hsa_circ_0079299 was lower in HCC tissues. Overexpression of hsa_circ_0079299 suppressed tumor growth in vitro and in vivo, retarded cell cycle progression while had no effect on cell migration and apoptosis. The inhibitory effect of hsa_circ_0079299 was partly mediated by PI3K/AKT/mTOR signaling pathway.

conclusionOur study shows that tumor suppressive role of hsa_circ_0079299 in HCC provides new recognition of circRNAs in cancers.

Indexed as

cell cyclecell proliferationcyclin B1liver cancer

Identifiers

PMID30655696
PMCPMC6322497
OpenAlexW2908433808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.