Evidence map›Paper›PMID 30655625›Full record

ReviewNature reviews. Endocrinology2019

Circadian rhythms and exercise - re-setting the clock in metabolic disease.

Brendan M Gabriel, Juleen R Zierath

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06601660 (Effect of Combined Physical Training At Different Times of the Day on Muscle and Adipose Tissue Remodeling, Metabolism and Physical Performance in Female Mice and Women with Obesity), which is not on this map. Cited by 221 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 7 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06601660 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Combined Physical Training At Different Times of the Day on Muscle and Adipose Tissue Remodeling, Metabolism and Physical Performance in Female Mice and Women with Obesity

TypeinterventionalSponsorState University of Minas GeraisRan2024 to 2025Enrolled60ConditionsObesity Type I and II, Obesity and OverweightArmsMorning Physical Training, Night Physical Training, No intervention
3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 7 syntheses or guidelines pooled it, 347 citations in OpenAlex.

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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Brendan M GabrielDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Juleen R ZierathDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. juleen.zierath@ki.se.ORCID http://orcid.org/0000-0001-6891-7497
Karolinska Institutet · SENovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perturbed diurnal rhythms are becoming increasingly evident as deleterious events in the pathology of metabolic diseases. Exercise is well characterized as a crucial intervention in the prevention and treatment of individuals with metabolic diseases. Little is known, however, regarding optimizing the timing of exercise bouts in order to maximize their health benefits. Furthermore, exercise is a potent modulator of skeletal muscle metabolism, and it is clear that skeletal muscle has a strong circadian profile. In humans, mitochondrial function peaks in the late afternoon, and the circadian clock might be inherently impaired in myotubes from patients with metabolic disease. Timing exercise bouts to coordinate with an individual's circadian rhythms might be an efficacious strategy to optimize the health benefits of exercise. The role of exercise as a Zeitgeber can also be used as a tool in combating metabolic disease. Shift work is known to induce acute insulin resistance, and appropriately timed exercise might improve health markers in shift workers who are at risk of metabolic disease. In this Review, we discuss the literature regarding diurnal skeletal muscle metabolism and the interaction with exercise bouts at different times of the day to combat metabolic disease.

Indexed as

Circadian ClocksCircadian RhythmExerciseExercise ToleranceFemaleHealthy LifestyleHumansMaleMetabolic DiseasesMuscle, SkeletalResistance Training

Identifiers

PMID30655625
OpenAlexW2910358458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.