Evidence map›Paper›PMID 30655605›Full record

ArticleOncogene2019

Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments.

Ivenise Carrero, Hsuan-Chen Liu, Andrew G Sikora, Aleksandar Milosavljevic

Abstract read
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In one paragraph

Article in Oncogene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  10. Role of the Ror family receptors in Wnt5a signaling.In vitro cellular & developmental biology. Animal · 2024
    Review
  11. Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ivenise Carrero *Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.
Hsuan-Chen Liu *Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX, USA.
Andrew G SikoraDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA. Andrew.Sikora@bcm.edu.
Aleksandar MilosavljevicMolecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA. amilosav@bcm.edu.

Funding

SOC CoreU54DA036134 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI GALAS, DAVID J., GERSTEIN, MARK BENDER · 2013 to 2018
$15.0M
NIDA NIH HHS U54 DA036134
6 · The paper itself

Abstract

Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer has in recent years emerged as the fastest growing type of HNSCC. Patients with HPV+ HNSCC have a better prognosis; however, the 5-year survival for both HPV+ and HPV- subtypes with recurrent or metastatic disease is poor. To gain insights into the tumor microenvironments of both HNSCC subtypes and identify potential therapeutic targets, we performed epigenomic deconvolution on 580 HNSCC samples from the TCGA dataset. Deconvolution revealed distinct molecular and histoepigenetic profiles of the two tumor subtypes, including their cellular composition, epigenomic profiles and gene expression for constituent cell types, and potential cancer cell-specific targets. Our analyses show that high abundance of both CD8 T-cells and B-cells explains better prognosis in HPV+ HNSCC. Deconvolution of gene expression profiles revealed higher expression of the immunotherapy target PD-1 in HPV+ immune cells compared to HPV- cells, suggesting that HPV+ tumors may preferentially benefit from PD-1 targeted therapy. Further analyses identified HPV+ and HPV- cancer cell surface proteins that can also serve as potential targets for therapy. Specifically, Wnt pathway receptor ROR2 is preferentially overexpressed in HPV+ subtypes, suggesting opportunities for development of targeted therapy based on HPV status. In summary, the comprehensive molecular and histoepigenetic analysis of tumor microenvironments by epigenomic deconvolution reveals potential novel biomarkers and targets for precision therapy of HNSCC.

Indexed as

Antigens, LyB-LymphocytesCD8-Positive T-LymphocytesCTLA-4 AntigenDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticGPI-Linked ProteinsHead and Neck NeoplasmsHumansImmunotherapyKaplan-Meier EstimateMolecular Targeted TherapyPapillomavirus InfectionsPrognosisProgrammed Cell Death 1 ReceptorAntigens, LyCTLA-4 AntigenCTLA4 protein, humanGPI-Linked ProteinsLY6K protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptor Tyrosine Kinase-like Orphan ReceptorsROR2 protein, human

Identifiers

PMID30655605
PMCPMC6756123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.