ArticleScientific reports2019
Tupanvirus-infected amoebas are induced to aggregate with uninfected cells promoting viral dissemination.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba.BMC biology · 2025Article
- Giant viruses inhibit superinfection by downregulating phagocytosis inJournal of virology · 2024Article
- The consequences of viral infection on protists.Communications biology · 2024Review
- Cytopathic effects in Mimivirus infection: understanding the kinetics of virus-cell interaction.Memorias do Instituto Oswaldo Cruz · 2024Article
- Social life of free-living amoebae in aquatic environment- comprehensive insights into interactions of free-living amoebae with neighboring microorganisms.Frontiers in microbiology · 2024Review
- Viral Prevalence and Genomic Xenology in the Coevolution of HzNV-2 (Nudiviridae) with HostInsects · 2023Article
- Giant Viruses as a Source of Novel Enzymes for Biotechnological Application.Pathogens (Basel, Switzerland) · 2022Review
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- Diversity of Giant Viruses InfectingFrontiers in microbiology · 2022Review
- Kinetic Analysis of Acanthamoeba castellanii Infected with Giant Viruses Quantitatively Revealed Process of Morphological and Behavioral Changes in Host Cells.Microbiology spectrum · 2021Article
- Marseilleviruses: An Update in 2021.Frontiers in microbiology · 2021Review
- Marseilleviridae Lineage B Diversity and Bunch Formation Inhibited by Galactose.Microbes and environments · 2021Article
- Article
- Virus goes viral: an educational kit for virology classes.Virology journal · 2020Article
- How Tupanvirus Degrades the Ribosomal RNA of Its Amoebal Host? The Ribonuclease T2 Track.Frontiers in microbiology · 2020Article
- Article
- Giant virus vs amoeba: fight for supremacy.Virology journal · 2019Review
- Fifteen Marseilleviruses Newly Isolated From Three Water Samples in Japan Reveal Local Diversity ofFrontiers in microbiology · 2019Article
- Kinetic Analysis of the Motility of Giant Virus-Infected Amoebae Using Phase-Contrast Microscopic Images.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of giant viruses in the last years has fascinated the scientific community due to virus particles size and genome complexity. Among such fantastic discoveries, we have recently described tupanviruses, which particles present a long tail, and has a genome that contains the most complete set of translation-related genes ever reported in the known virosphere. Here we describe a new kind of virus-host interaction involving tupanvirus. We observed that tupanvirus-infected amoebas were induced to aggregate with uninfected cells, promoting viral dissemination and forming giant host cell bunches. Even after mechanical breakdown of bunches, amoebas reaggregated within a few minutes. This remarkable interaction between infected and uninfected cells seems to be promoted by the expression of a mannose receptor gene. Our investigations demonstrate that the pre-treatment of amoebas with free mannose inhibits the formation of bunches, in a concentration-dependent manner, suggesting that amoebal-bunch formation correlates with mannose receptor gene expression. Finally, our data suggest that bunch-forming cells are able to interact with uninfected cells promoting the dissemination and increase of tupanvirus progeny.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.