ArticleNature communications2019
Prefrontal mechanisms combining rewards and beliefs in human decision-making.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
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- Age-Related Differences in Neural Networks for Error Detection and Inhibitory Control: A LORETA-Based Comparative Study.Brain sciences · 2026Article
- Individualized Subcortical Functional Brain Organization Is Related to Diagnosis, Symptoms, and Behavior in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior.Nature communications · 2025Article
- Neural mechanisms of confidence propagation in hierarchical partially observable decision-making.iScience · 2025Article
- Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder.Translational psychiatry · 2025Article
- Neural and Computational Mechanisms of Motivation and Decision-making.Journal of cognitive neuroscience · 2024Article
- Heuristics in risky decision-making relate to preferential representation of information.Nature communications · 2024Article
- The neural correlates of memory integration in value-based decision-making during human spatial navigation.Neuropsychologia · 2024Article
- Mapping expectancy-based appetitive placebo effects onto the brain in women.Nature communications · 2024Article
- Anterior cingulate and medial prefrontal cortex oscillations underlie learning alterations in trait anxiety in humans.Communications biology · 2023Article
- Modulation of Motor Vigor by Expectation of Reward Probability Trial-by-Trial Is Preserved in Healthy Ageing and Parkinson's Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Thalamic regulation of frontal interactions in human cognitive flexibility.PLoS computational biology · 2022Article
- Gaze-dependent evidence accumulation predicts multi-alternative risky choice behaviour.PLoS computational biology · 2022Article
- A One-Shot Shift from Explore to Exploit in Monkey Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Application of Cognitive Bias Testing in Neuropsychiatric Disorders: A Mini-Review Based on Animal Studies.Frontiers in behavioral neuroscience · 2022Review
- Multi-Modal Integration of EEG-fNIRS for Characterization of Brain Activity Evoked by Preferred Music.Frontiers in neurorobotics · 2022Article
- Computational models of adaptive behavior and prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In uncertain and changing environments, optimal decision-making requires integrating reward expectations with probabilistic beliefs about reward contingencies. Little is known, however, about how the prefrontal cortex (PFC), which subserves decision-making, combines these quantities. Here, using computational modelling and neuroimaging, we show that the ventromedial PFC encodes both reward expectations and proper beliefs about reward contingencies, while the dorsomedial PFC combines these quantities and guides choices that are at variance with those predicted by optimal decision theory: instead of integrating reward expectations with beliefs, the dorsomedial PFC built context-dependent reward expectations commensurable to beliefs and used these quantities as two concurrent appetitive components, driving choices. This neural mechanism accounts for well-known risk aversion effects in human decision-making. The results reveal that the irrationality of human choices commonly theorized as deriving from optimal computations over false beliefs, actually stems from suboptimal neural heuristics over rational beliefs about reward contingencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.