ArticleNature communications2019
CRISPR analysis suggests that small circular single-stranded DNA smacoviruses infect Archaea instead of humans.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 61 citations in OpenAlex.
- Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids.Nature communications · 2026Article
- Predicting unknown mammalian viral hosts with Dynamic Positive-Unlabeled learning.Nature communications · 2026Article
- Virome of post-weaned diarrhoeic pigs and healthy cohorts in England.Virology journal · 2026Article
- Comparison of gut viromes across captive mammals reveals extensive genetic diversity in bacteriophage dark matter and mammalian viruses.Zoological research · 2026Article
- Healthy and moribund Zhikong scallops (mSystems · 2025Article
- Unveiling the Virome of Wild Birds: Exploring CRESS-DNA Viral Dark Matter.Genome biology and evolution · 2024Article
- First Detection and Characterization ofViruses · 2024Article
- 2024 Smacoviridae family update: 59 new species in seven genera.Archives of virology · 2024Review
- Metagenome-assembled microvirus and cressdnavirus genomes from fecal samples of house mice (Microbiology resource announcements · 2024Article
- Full-genome sequencing of dozens of new DNA viruses found in Spanish bat feces.Microbiology spectrum · 2024Article
- Reply to: Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut.Nature communications · 2024Article
- Diverse Circular DNA Viral Communities in Blood, Oral, and Fecal Samples of Captive Lemurs.Viruses · 2024Article
- Metagenomic Identification of Novel Eukaryotic Viruses with Small DNA Genomes in Pheasants.Animals : an open access journal from MDPI · 2024Article
- Article
- The crystal structure of the human smacovirus 1 Rep domain.Acta crystallographica. Section F, Structural biology communications · 2023Article
- A compendium of viruses from methanogenic archaea reveals their diversity and adaptations to the gut environment.Nature microbiology · 2023Article
- Searching for a Reliable Viral Indicator of Faecal Pollution in Aquatic Environments.Journal of microbiology (Seoul, Korea) · 2023Review
- Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut.Nature communications · 2022Article
- Article
- Phylogenetic Diversity of Animal Oral and Gastrointestinal Viromes Useful in Surveillance of Zoonoses.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smacoviridae is a family of small (~2.5 Kb) CRESS-DNA (Circular Rep Encoding Single-Stranded (ss) DNA) viruses. These viruses have been found in faeces, were thought to infect eukaryotes and are suspected to cause gastrointestinal disease in humans. CRISPR-Cas systems are adaptive immune systems in prokaryotes, wherein snippets of genomes from invaders are stored as spacers that are interspersed between a repeated CRISPR sequence. Here we report several spacer sequences in the faecal archaeon Candidatus Methanomassiliicoccus intestinalis matching smacoviruses, implicating the archaeon as a firm candidate for a host. This finding may be relevant to understanding the potential origin of smacovirus-associated human diseases. Our results support that CRESS-DNA viruses can infect non-eukaryotes, which would mean that smacoviruses are the viruses with the smallest genomes to infect prokaryotes known to date. A probable target strand bias suggests that, in addition to double-stranded DNA, the CRISPR-Cas system can target ssDNA.
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