ArticleDiabetes2019
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes.Hormone research in paediatrics · 2024Guideline
- The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.Reviews in medical virology · 2021Pooled it
- Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.Diabetologia · 2021Trial
- Genetic risk in extremely early onset type 1 diabetes.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Article
- Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study.Diabetes care · 2025Review
- Time to reframe the disease staging system for type 1 diabetes.The lancet. Diabetes & endocrinology · 2024Review
- Article
- Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes.Genome medicine · 2024Article
- The countdown to type 1 diabetes: when, how and why does the clock start?Diabetologia · 2023Review
- Incomplete time-series gene expression in integrative study for islet autoimmunity prediction.Briefings in bioinformatics · 2023Article
- Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study.Diabetes care · 2022Article
- Article
- Supplementation withBMJ open · 2021Article
- First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child's genetic risk.Diabetologia · 2021Article
- Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges.Frontiers in endocrinology · 2021Review
- A combined risk score enhances prediction of type 1 diabetes among susceptible children.Nature medicine · 2020Article
- Article
- Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.The Journal of clinical endocrinology and metabolism · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 10 institutions in 4 countries.
Markus HippichInstitute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
Andreas BeyerleinInstitute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.ORCID 0000-0001-6603-5036
William A HagopianPacific Northwest Research Institute, Seattle, WA.
Jeffrey P KrischerHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
Kendra VehikHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
Jan KnoopInstitute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
Christiane WinkerInstitute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
Jorma ToppariDepartment of Pediatrics, Turku University Hospital, and Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Åke LernmarkDepartment of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmo, Sweden.
Marian J RewersBarbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO.
Andrea K SteckBarbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO.ORCID 0000-0002-5931-9484
Jin-Xiong SheCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA.
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
Catherine C RobertsonCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.ORCID 0000-0002-6563-8334
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.ORCID 0000-0003-3872-7793
Ezio BonifacioForschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany anette-g.ziegler@helmholtz-muenchen.de ezio.bonifacio@tu-dresden.de.
Anette-G ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany anette-g.ziegler@helmholtz-muenchen.de ezio.bonifacio@tu-dresden.de.ORCID 0000-0002-6290-5548
TEDDY Study Group
Teddy Study Group
Helmholtz Zentrum München · DEUniversity of Virginia · USTUM Klinikum · DEUniversity of Colorado Anschutz Medical Campus · USUniversity of South Florida · USPacific Northwest Diabetes Research Institute · USAugusta University · USLund University · SENational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Turku · FI
Funding
Data Coordinating Center (DCC)for the Consortium for Identification of EnvironmenUC4DK095300 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2011 to 2011
$56.0MData Coordinating CenterU01DK063790 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2002 to 2006
$50.1MColorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MVector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MNIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)UC4DK117483 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2017 to 2020
$30.4MEstablish a Data Coordinating Center (DCC) for the Consortium for Identification UC4DK100238 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2014
$28.9MThe Study of Epigenetics and Infections in The Environmental Determinants of Diabetes in the Young (TEDDY)UC4DK112243 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2016
$27.0MData Coordinating Center (DCC) for the Consortium for Identification of Environmental Determinants of Diabetes in the Young (TEDDY) StudyUC4DK106955 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2015 to 2015
$20.0MThe Environmental Determinants of Diabetes in Young (TEDDY0U01DK063863 · NIDDK · HOSPITAL DISTRICT OF SOUTHWEST FINLAND · PI TOPPARI, JORMA · 2003 to 2022
$13.5MThe Environmental Triggers of Diabetes (TEDDY) in SwedenU01DK063861 · NIDDK · UNIVERSITY OF WASHINGTON · PI LERNMARK, AKE · 2003 to 2022
$13.4MTHE TEDDY STUDY - COLORADO CLINICAL CENTERU01DK063821 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2003 to 2022
$12.3MThe TEDDY Study: Georgia/Florida Clinical CenterU01DK063865 · NIDDK · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MCINDOE, RICHARD A. · 2003 to 2022
$12.3MNCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001082NIDDK NIH HHS DP3 DK111906NIDDK NIH HHS HHSN267200700014CNIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK063790NIDDK NIH HHS U01 DK063821NIDDK NIH HHS U01 DK063829NIDDK NIH HHS U01 DK063836NIDDK NIH HHS U01 DK063861NIDDK NIH HHS U01 DK063863NIDDK NIH HHS U01 DK063865NIDDK NIH HHS UC4 DK063821NIDDK NIH HHS UC4 DK063829NIDDK NIH HHS UC4 DK063836NIDDK NIH HHS UC4 DK063861NIDDK NIH HHS UC4 DK063863NIDDK NIH HHS UC4 DK063865NIDDK NIH HHS UC4 DK095300NIDDK NIH HHS UC4 DK100238NIDDK NIH HHS UC4 DK106955NIDDK NIH HHS UC4 DK112243NIDDK NIH HHS UC4 DK117483
Abstract
The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (
Indexed as
AutoantibodiesAutoimmunityDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseGenotypeHLA-DQ AntigensHumansIslets of LangerhansProportional Hazards ModelsRisk FactorsAutoantibodiesHLA-DQ Antigens
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.