Evidence map›Paper›PMID 30655377›Full record

ArticleHaematologica2019

Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation.

Nico Gagelmann, Diderik-Jan Eikema, Matthias Stelljes, Dietrich Beelen, Liesbeth de Wreede, Ghulam Mufti, Nina Simone Knelange, Dietger Niederwieser, Lone S Friis, Gerhard Ehninger and 16 more

Abstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Article
  4. Therapy of high-risk myelodysplastic syndromes.Bone marrow transplantation · 2026
    Review
  5. Review
  6. Article
  7. Allogeneic Transplant for CMML.Current hematologic malignancy reports · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Lower risk but high risk.Hematology. American Society of Hematology. Education Program · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Nico GagelmannUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Diderik-Jan EikemaEBMT Statistics, Leiden, the Netherlands.
Matthias StelljesUniversity of Münster, Germany.
Dietrich BeelenDepartment of Bone Marrow Transplantation, West German Cancer Center, University Hospital of Essen, Germany.
Liesbeth de WreedeEBMT Statistics, Leiden, the Netherlands.
Ghulam MuftiGKT School of Medicine, London, UK.
Nina Simone KnelangeEBMT Data Office, Leiden, the Netherlands.
Dietger NiederwieserUniversity Hospital Leipzig, Germany.
Lone S FriisRigshospitalet, Copenhagen, Denmark.
Gerhard EhningerUniversitätsklinikum Dresden, Germany.
Arnon NaglerChaim Sheba Medical Center, Tel-Hashomer, Israel.
Ibrahim Yakoub-AghaCHU de Lille, LIRIC, INSERM U995, Université Lille2, France.
Ellen MeijerVU University Medical Center, Amsterdam, the Netherlands.
Per LjungmanKarolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Johan MaertensUniversity Hospital Gasthuisberg, Leuven, Belgium.
Lothar KanzUniversität Tübingen, Germany.
Lucia Lopez-CorralHospital Clínico, Salamanca, Spain.
Arne BrechtDeutsche Klinik für Diagnostik, Wiesbaden, Germany.
Charles CraddockCentre for Clinical Haematology, Birmingham, UK.
Jürgen FinkeUniversity of Freiburg, Germany.
Jan J CornelissenErasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Paolo BernasconiFondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Patrice ChevallierCHU Nantes, France.
Jorge SierraHospital Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain.
Marie RobinHopital St. Louis, Paris, France.
Nicolaus KrögerUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany nkroeger@uke.uni-hamburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical and transplant-related variables prognostic of outcome. Then, cross-validation was performed to evaluate the validity and consistency of the model. Seven independent risk factors for survival were identified: age ≥50 years, matched unrelated donor, Karnofsky Performance Status <90%, very poor cytogenetics or monosomal karyotype, positive cytomegalovirus status of the recipient, blood blasts >1%, and platelet count ≤50 × 10

Indexed as

Models, StatisticalNomogramsAdolescentAdultAgedCohort StudiesFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedMyelodysplastic SyndromesPrognosisRisk AssessmentRisk Factors

Identifiers

PMID30655377
PMCPMC6518902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.