Evidence map›Paper›PMID 30655373›Full record

ArticleHaematologica2019

Performance analysis of AL amyloidosis cardiac biomarker staging systems with special focus on renal failure and atrial arrhythmia.

Tobias Dittrich, Axel Benner, Christoph Kimmich, Fabian Aus dem Siepen, Kaya Veelken, Arnt V Kristen, Tilmann Bochtler, Hugo A Katus, Carsten Müller-Tidow, Ute Hegenbart and 1 more

Abstract read
In one paragraph

Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Biomarkers in AL Amyloidosis.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK).Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Amyloidosis in Heart Failure.Current heart failure reports · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Tobias DittrichDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital.
Axel BennerDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg.
Christoph KimmichDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital.
Fabian Aus dem SiepenAmyloidosis Center, Heidelberg University Hospital.
Kaya VeelkenDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital.
Arnt V KristenAmyloidosis Center, Heidelberg University Hospital.
Tilmann BochtlerDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital.
Hugo A KatusDepartment of Internal Medicine III, Division of Cardiology, Heidelberg University Hospital, Germany.
Carsten Müller-TidowDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital.
Ute HegenbartDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital stefan.schoenland@med.uni-heidelberg.de ute.hegenbart@med.uni-heidelberg.de.
Stefan O SchönlandDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital stefan.schoenland@med.uni-heidelberg.de ute.hegenbart@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic light chain amyloidosis is a rare and life-threatening disorder, for which accurate risk stratification is crucial. Current cardiac staging systems (MAYO2004, MAYO3b, and MAYO2012) are mainly based on biomarkers, which have uncertain reliability in the context of atrial fibrillation, arrhythmia or pacemaker stimulation as well as renal insufficiency. We compared the performance of the established staging systems with particular regard to these comorbidities in 1,224 patients with systemic light chain amyloidosis diagnosed at our center from July 2002 until March 2017. We first characterized the subsets with an estimated glomerular filtration rate <50 mL/min/1.73 m

Indexed as

Glomerular Filtration RateAdultAgedAged, 80 and overAtrial FibrillationBiomarkersFemaleFollow-Up StudiesHumansImmunoglobulin Light-chain AmyloidosisMaleMiddle AgedPrognosisRenal InsufficiencyRetrospective StudiesRisk FactorsBiomarkers

Identifiers

PMID30655373
PMCPMC6601086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.