Evidence map›Paper›PMID 30655356›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice.

Sam A Golden, Michelle Jin, Conor Heins, Marco Venniro, Michael Michaelides, Yavin Shaham

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026
    Review
  5. Article
  6. Sexual Dimorphism in c-Fos Networks Governing Aggression.bioRxiv : the preprint server for biology · 2026
    Article
  7. Dopamine modulation of aggression.Psychopharmacology · 2026
    Review
  8. Article
  9. Dichotomous Regulation of Social Behaviors by Nucleus Accumbens Neurons in Female and Male Syrian Hamsters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Serotonin modulates nucleus accumbens circuits to suppress aggression.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  17. How dopamine guides our social world.Pharmacological reviews · 2025
    Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sam A GoldenIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224 sagolden@uw.edu yshaham@intra.nida.nih.gov.ORCID 0000-0002-2104-2272
Michelle JinIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0002-8696-1958
Conor HeinsIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224.
Marco VenniroIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0001-7653-957X
Michael MichaelidesIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224.ORCID 0000-0003-0398-4917
Yavin ShahamIntramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland 21224 sagolden@uw.edu yshaham@intra.nida.nih.gov.ORCID 0000-0002-8242-3319
National Institutes of Health · US

Funding

Neurobiology Of Relapse To Opiate and Psychostimulant DrugsZIADA000434 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2009 to 2025
$39.8M
Role of the nucleus accumbens in regulating aggression reward.FI2GM117583 · NIGMS · U.S. NATIONAL INSTITUTE ON DRUG ABUSE · PI GOLDEN, SAM · 2016 to 2016
–
NIDA NIH HHS K99 DA045662NIGMS NIH HHS FI2 GM117583
6 · The paper itself

Abstract

We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence. Here we studied the role of nucleus accumbens (NAc) dopamine receptor (Drd)1- and Drd2-expressing neurons in aggression self-administration and aggression seeking. We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence Day 1. We used immunohistochemistry and

Indexed as

AggressionAnimalsConditioning, OperantMaleMiceMice, TransgenicNeuronsNucleus AccumbensReceptors, Dopamine D1Receptors, Dopamine D2Drd1 protein, mouseDRD2 protein, mouseReceptors, Dopamine D1Receptors, Dopamine D2accumbensaddictionaggressionmotivationrelapsereward

Identifiers

PMID30655356
PMCPMC6435830
OpenAlexW2908627166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.