Evidence map›Paper›PMID 30655340›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.

Aaditya Khatri, Bryan D Kraft, Purushothama Rao Tata, Scott H Randell, Claude A Piantadosi, Ann Marie Pendergast

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Article
  6. ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Innate immune responses in pneumonia.Pneumonia (Nathan Qld.) · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aaditya KhatriDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710.
Bryan D KraftDepartment of Medicine, Duke University Medical Center, Durham, NC 27710.
Purushothama Rao TataDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
Scott H RandellDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599.
Claude A PiantadosiDepartment of Medicine, Duke University Medical Center, Durham, NC 27710.
Ann Marie PendergastDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710; ann.pendergast@duke.edu.
Duke Medical Center · USDuke University Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Role of Abl Kinases in immune cell signalingR01AI056266 · NIAID · DUKE UNIVERSITY · PI PENDERGAST, ANN MARIE · 2004 to 2015
$3.6M
Novel target for therapy refractory lung tumorsR01CA195549 · NCI · DUKE UNIVERSITY · PI PENDERGAST, ANN MARIE · 2015 to 2019
$1.8M
Mitochondrial quality control and alveolar damage resolution after acute lung injuryR01HL135239 · NHLBI · DUKE UNIVERSITY · PI WELTY-WOLF, KAREN E · 2017 to 2020
$1.6M
To define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationR00HL127181 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2017 to 2019
$738k
Role of S-nitrosothiols in Akt1 signaling and pneumonia resolutionK08HL130557 · NHLBI · DUKE UNIVERSITY · PI KRAFT, BRYAN D. · 2017 to 2021
$591k
Regulation of cell permeability by Abl kinases and implications for the treating of acute lung injuryF30HL126448 · NHLBI · DUKE UNIVERSITY · PI KHATRI, AADITYA · 2015 to 2017
$117k
BLRD VA I01 BX004289NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA195549NHLBI NIH HHS F30 HL126448NHLBI NIH HHS K08 HL130557NHLBI NIH HHS R00 HL127181NHLBI NIH HHS R01 HL135239NIAID NIH HHS R01 AI056266NIAID NIH HHS UC6 AI058607NIDDK NIH HHS P30 DK065988NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of molecules that might be therapeutically targeted in response to infections to promote activation of progenitor cell types remains elusive. Here, we report that loss of

Indexed as

Alveolar Epithelial CellsAnimalsBronchiolesCell DifferentiationCell LineFemaleHumansLungMaleMiceMice, Inbred C57BLPneumonia, BacterialProto-Oncogene Proteins c-ablPulmonary AlveoliRegenerationRespiratory MucosaProto-Oncogene Proteins c-ablSCGB1A1 protein, humanUteroglobinAbl kinasesalveolar injurylung regenerationpneumonia

Identifiers

PMID30655340
PMCPMC6358689
OpenAlexW2910276791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.