Evidence map›Paper›PMID 30655328›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Precision Cardio-Oncology.

Alexandra D Dreyfuss, Paco E Bravo, Constantinos Koumenis, Bonnie Ky

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Additional Value of Cardiac Assessment With OncologicReviews in cardiovascular medicine · 2026
    Article
  3. Advancing cardiac tumor diagnosis: evaluatingAmerican journal of cardiovascular disease · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Doxorubicin-induced cardiotoxicity and risk factors.International journal of cardiology. Heart & vasculature · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Advancing Cardio-Oncology in Asia.Korean circulation journal · 2023
    Review
  14. Article
  15. Non-invasive imaging as the cornerstone of cardiovascular precision medicine.European heart journal. Cardiovascular Imaging · 2022
    Review
  16. Artificial intelligence and imaging: Opportunities in cardio-oncology.American heart journal plus : cardiology research and practice · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexandra D DreyfussDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Paco E BravoDivision of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Constantinos KoumenisDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Bonnie KyDivision of Cardiology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and bonnie.ky@uphs.upenn.edu.
University of Pennsylvania · US

Funding

NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
Multimarker Risk Prediction in Cancer Therapy CardiotoxicityR01HL118018 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2014 to 2018
$3.7M
NCATS NIH HHS TL1 TR001880NHLBI NIH HHS R01 HL118018
6 · The paper itself

Abstract

Modern oncologic therapies and care have resulted in a growing population of cancer survivors with comorbid, chronic health conditions. As an example, many survivors have an increased risk of cardiovascular complications secondary to cardiotoxic systemic and radiation therapies. In response, the field of cardio-oncology has emerged as an integral component of oncologic patient care, committed to the early diagnosis and treatment of adverse cardiac events. However, as current clinical management of cancer therapy-related cardiovascular disease remains limited by a lack of phenotypic data, implementation of precision medicine approaches has become a focal point for deep phenotyping strategies. In particular, -omics approaches (a field of study in biology ending in -omic, such as genomics, proteomics, or metabolomics) have shown enormous potential in identifying sensitive biomarkers of cardiovascular disease, applying sophisticated, pattern-revealing technologies to growing databases of biologic molecules. Moreover, the use of -omics to inform radiologic strategies may add a dimension to future clinical practices. In this review, we present a paradigm for a precision medicine approach to the care of cardiotoxin-exposed cancer patients. We discuss the role of current imaging techniques; demonstrate how -omics can advance our understanding of disease phenotypes; and describe how molecular imaging can be integrated to personalize surveillance and therapeutics, ultimately reducing cardiovascular morbidity and mortality in cancer patients and survivors.

Indexed as

CardiotoxicityMedical OncologyPrecision MedicineBiomarkersHumansMolecular ImagingRadiation InjuriesBiomarkerscardio-oncologycardiotoxicity-omicsprecision cardio-oncologyprecision medicine

Identifiers

PMID30655328
PMCPMC6448460
OpenAlexW2910272120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.