Evidence map›Paper›PMID 30655296›Full record

ArticleThe Journal of cell biology2019

Myosin IIB assembly state determines its mechanosensitive dynamics.

Eric S Schiffhauer, Yixin Ren, Vicente A Iglesias, Priyanka Kothari, Pablo A Iglesias, Douglas N Robinson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Models of Cellular Mechanosensation.Results and problems in cell differentiation · 2026
    Review
  4. Review
  5. Nuclear destabilisation - a possible genesis of cancer?Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  6. Article
  7. Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Non-Muscle Myosin II A: Friend or Foe in Cancer?International journal of molecular sciences · 2024
    Review
  11. Structure, regulation, and mechanisms of nonmuscle myosin-2.Cellular and molecular life sciences : CMLS · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The mechanobiome: a goldmine for cancer therapeutics.American journal of physiology. Cell physiology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eric S SchiffhauerDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-7229-842X
Yixin RenDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD.
Vicente A IglesiasDepartment of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD.
Priyanka KothariDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD.
Pablo A IglesiasDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-0840-155X
Douglas N RobinsonDepartment of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD dnr@jhmi.edu.ORCID 0000-0003-1236-4891
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
The Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3M
Force-sensitive macromolecular cytoskeletal assemblyR01GM109863 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N, ROCK, RONALD S · 2014 to 2017
$1.1M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
Positive and negative regulation of the cytokinesis contractility controllerF31GM122258 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KOTHARI, PRIYANKA · 2018 to 2019
$72k
NIGMS NIH HHS F31 GM122258NIGMS NIH HHS R01 GM066817NIGMS NIH HHS R01 GM109863NIGMS NIH HHS T32 GM007445NIH HHS S10 OD016374
6 · The paper itself

Abstract

Dynamical cell shape changes require a highly sensitive cellular system that can respond to chemical and mechanical inputs. Myosin IIs are key players in the cell's ability to react to mechanical inputs, demonstrating an ability to accumulate in response to applied stress. Here, we show that inputs that influence the ability of myosin II to assemble into filaments impact the ability of myosin to respond to stress in a predictable manner. Using mathematical modeling for

Indexed as

Mechanotransduction, CellularModels, BiologicalAnimalsDictyosteliumHeLa CellsHumansJurkat CellsMiceNIH 3T3 CellsNonmuscle Myosin Type IIBProtein Kinase CProtein Kinase C zetaProtozoan ProteinsNonmuscle Myosin Type IIBProtein Kinase CProtein Kinase C zetaProtozoan Proteins

Identifiers

PMID30655296
PMCPMC6400566
OpenAlexW2910119774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.