Evidence map›Paper›PMID 30655255›Full record

ArticleAJNR. American journal of neuroradiology2019

Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration.

S Gaudino, M Martucci, A Botto, E Ruberto, E Leone, A Infante, A Ramaglia, M Caldarelli, P Frassanito, F M Triulzi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S GaudinoFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia Simona.gaudino@gmail.com.ORCID 0000-0003-1681-4343
M MartucciOperative Unit di Neuroradiologia (M.M.), Azienda Ospedaliera, Università di Padova, Padova, Italy.ORCID 0000-0002-0801-0380
A BottoFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0002-2219-6484
E RubertoFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0001-7223-8462
E LeoneFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0003-0739-7082
A InfanteFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0003-4407-2631
A RamagliaFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0003-2998-3322
M CaldarelliNeurochirurgia infantile (M.C., P.F.), Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere, Rome, Italy.ORCID 0000-0002-2111-3800
P FrassanitoNeurochirurgia infantile (M.C., P.F.), Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere, Rome, Italy.ORCID 0000-0003-0071-3126
F M TriulziNeuroradiology Unit (F.M.T.), Foundation Istituto di Ricovero e Cura a Carattere Scientifico, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-5428-7217
C ColosimoFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia.ORCID 0000-0003-3800-3648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDynamic susceptibility contrast MR perfusion imaging has limited results in children due to difficulties in reproducing technical standards derived from adults. This prospective, multicenter study aimed to determine DSC feasibility and quality in children using custom administration of a standard dose of gadolinium. MATERIALS AND

methodsEighty-three consecutive children with brain tumors underwent DSC perfusion with a standard dose of gadobutrol administered by an automated power injector. The location and size of intravenous catheters and gadobutrol volume and flow rates were reported, and local and/or systemic adverse effects were recorded. DSC was qualitatively evaluated by CBV maps and signal intensity-time curves and quantitatively by the percentage of signal drop and full width at half-maximum, and the data were compared with the standards reported for adults. Quantitative data were grouped by flow rate, and differences among groups were assessed by analysis of covariance and tested for statistical significance with a

resultsNo local or systemic adverse events were recorded independent of catheter location (63 arm, 14 hand, 6 foot), size (24-18 ga), and flow rates (1-5 mL/s). High-quality CBV maps and signal intensity-time curves were achieved in all patients, and quantitative evaluations were equal or superior to those reported for adults. No significant differences (

conclusionsA custom administration of a standard dose of gadobutrol allows safe and high-quality DSC MR perfusion imaging in children.

Indexed as

AdolescentBrain NeoplasmsChildChild, PreschoolContrast MediaFeasibility StudiesFemaleHumansInfantMagnetic Resonance ImagingMaleNeuroimagingOrganometallic CompoundsPerfusion ImagingProspective StudiesContrast MediagadobutrolOrganometallic Compounds

Identifiers

PMID30655255
PMCPMC7028630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.