ArticleNeuron2019
Ionotropic Receptors Specify the Morphogenesis of Phasic Sensors Controlling Rapid Thermal Preference in Drosophila.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed.
- Cold sensing by a glutamate receptor drives avoidance behavior in Drosophila larvae.Current biology : CB · 2026Article
- Mosquito heat and humidity detection in host seeking and oviposition behavior.Current opinion in neurobiology · 2026Review
- Functional conservation of IR75q.2 in the recognition of volatile acids and aldehydes in two Spodoptera species.Crop health · 2026Article
- The Cellular and Circuit Basis of Temperature Sensation inAnnual review of neuroscience · 2026Review
- Early hexapod genomes reveal the deep origin of insect gustatory and odorant receptors.Nature communications · 2026Article
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- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
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- Morphological specializations of mosquito COProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptome Screening and Identification of Chemosensory Genes in the Goji Berry Psyllid,Biology · 2025Article
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- Evolution of temperature preference behaviour amongiScience · 2025Article
- A genome-wide association study implicates the olfactory system inbioRxiv : the preprint server for biology · 2025Article
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila.Communications biology · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
10 more citing papers are in PubMed but not listed here.
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13 authors.
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Abstract
Thermosensation is critical for avoiding thermal extremes and regulating body temperature. While thermosensors activated by noxious temperatures respond to hot or cold, many innocuous thermosensors exhibit robust baseline activity and lack discrete temperature thresholds, suggesting they are not simply warm and cool detectors. Here, we investigate how the aristal Cold Cells encode innocuous temperatures in Drosophila. We find they are not cold sensors but cooling-activated and warming-inhibited phasic thermosensors that operate similarly at warm and cool temperatures; we propose renaming them "Cooling Cells." Unexpectedly, Cooling Cell thermosensing does not require the previously reported Brivido Transient Receptor Potential (TRP) channels. Instead, three Ionotropic Receptors (IRs), IR21a, IR25a, and IR93a, specify both the unique structure of Cooling Cell cilia endings and their thermosensitivity. Behaviorally, Cooling Cells promote both warm and cool avoidance. These findings reveal a morphogenetic role for IRs and demonstrate the central role of phasic thermosensing in innocuous thermosensation. VIDEO ABSTRACT.
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