Evidence map›Paper›PMID 30654773›Full record

SynthesisBMC complementary and alternative medicine2019

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.

N Alammar, L Wang, B Saberi, J Nanavati, G Holtmann, R T Shinohara, G E Mullin

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613153 (Peppermint Oil as an Alternative Treatment for Children With Bladder and Bowel Dysfunction), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05613153 naenrolling by invitationnot on this mapstarted 2022, after this paper: background citation

Peppermint Oil as an Alternative Treatment for Children With Bladder and Bowel Dysfunction: A Prospective Study

TypeinterventionalSponsorChildren's Hospital of Orange CountyRan2022 to 2026Enrolled30ConditionsBladder and Bowel DysfunctionArmsPeppermint Oil
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 215 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Review
  6. Diagnosis and treatment of irritable bowel syndrome with diarrhea: Key clinical considerations.Journal of the American Association of Nurse Practitioners · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

N AlammarThe Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0002-1413-3141
L WangThe Johns Hopkins School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1338-2100
B SaberiThe Division of Liver Medicine, Gastroenterology, The Mount Sinai Hospital, New York, NY, USA.ORCID http://orcid.org/0000-0002-7157-5827
J NanavatiThe Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0002-8356-0278
G HoltmannDepartment of Gastroenterology & Hepatology, Princess Alexandra Hospital, Brisbane, University of Queensland, QLD, Brisbane, Australia.ORCID http://orcid.org/0000-0002-0206-2358
R T ShinoharaDepartment of Biostatistics, Epidemiology, & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8627-8203
G E MullinThe Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. gmullin1@jhmi.edu.ORCID http://orcid.org/0000-0001-5317-6788
Johns Hopkins University · USMount Sinai Hospital · USThe University of Queensland · AUUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeppermint oil (PO) has intrinsic properties that may benefit patients with irritable bowel syndrome (IBS) symptoms. The study objective was to determine the effect of peppermint oil in the treatment of the IBS.

methodsWe systematically searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane CENTRAL), ClinicalTrials.gov, EMBASE (Ovid), and Web of Science for randomized controlled trials (RCTs) of PO for IBS. We appraised the eligible studies by the Cochrane risk of bias tool. We performed random-effects meta-analysis on primary outcomes including global improvement in IBS symptoms and abdominal pain. A PRISMA-compliant study protocol is registered in PROSPERO Register [2016, CRD42016050917].

resultsTwelve randomized trials with 835 patients were included. For global symptom improvement, the risk ratio (RR) from seven RCTs for the effect of PO (n = 253) versus placebo (n = 254) on global symptoms was 2.39 [95% confidence interval (CI): 1.93, 2.97], I

conclusionsIn the most comprehensive meta-analysis to date, PO was shown to be a safe and effective therapy for pain and global symptoms in adults with IBS.

Indexed as

HumansIrritable Bowel SyndromeMentha piperitaPlant OilsTreatment Outcomepeppermint oilPlant OilsAbdominal painGlobal symptom reliefIBSIrritable bowel syndromeMeta-analysisPeppermint oilPRISMA

Identifiers

PMID30654773
PMCPMC6337770
OpenAlexW2914610390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.