ArticleThe American journal of psychiatry2019
Age-Associated Deviations of Amygdala Functional Connectivity in Youths With Psychosis Spectrum Disorders: Relevance to Psychotic Symptoms.
Article in The American journal of psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily ΔBiological psychiatry global open science · 2025Article
- Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review.Translational psychiatry · 2025Review
- Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia.Frontiers in psychiatry · 2025Article
- Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia.Frontiers in psychiatry · 2024Article
- Amygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS.Translational psychiatry · 2023Article
- Limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia.European archives of psychiatry and clinical neuroscience · 2022Article
- Elevated emotion reactivity and emotion regulation in individuals at clinical high risk for developing psychosis and those diagnosed with a psychotic disorder.Early intervention in psychiatry · 2022Article
- Neural alterations of emotion processing in atypical trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2022Article
- Aberrant default mode connectivity in adolescents with early-onset psychosis: A resting state fMRI study.NeuroImage. Clinical · 2022Article
- Neuroimaging brain growth charts: A road to mental health.Psychoradiology · 2021Article
- Maternal parenting behavior and functional connectivity development in children: A longitudinal fMRI study.Developmental cognitive neuroscience · 2021Article
- Stress impacts corticoamygdalar connectivity in an age-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Neuroimaging Phenotypes Associated With Risk and Resilience for Psychosis and Autism Spectrum Disorders in 22q11.2 Microdeletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Physical activity and aerobic fitness in relation to local and interhemispheric functional connectivity in adolescents' brains.Brain and behavior · 2021Article
- Adolescent Neurodevelopment and Vulnerability to Psychosis.Biological psychiatry · 2021Review
- Considerations When Characterizing Adolescent Neurocognitive Development.Biological psychiatry · 2021Article
- Functional connectome fingerprinting accuracy in youths and adults is similar when examined on the same day and 1.5-years apart.Human brain mapping · 2020Article
- Resting-State Functional Network Organization Is Stable Across Adolescent Development for Typical and Psychosis Spectrum Youth.Schizophrenia bulletin · 2020Article
- Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia.NeuroImage. Clinical · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors created normative growth charts of amygdala functional connectivity in typically developing youths, assessed age-associated deviations of these trajectories in youths with psychosis spectrum disorders, and explored how these disruptions are related to clinical symptomatology.
methodsResting-state functional neuroimaging data from four samples (three cross-sectional, one longitudinal) were collected for 1,062 participants 10-25 years of age (622 typically developing control youths, 194 youths with psychosis spectrum disorders, and 246 youths with other psychopathology). The authors assessed deviations in the psychosis spectrum and other psychopathology groups in age-related changes in resting-state functional MRI amygdala-to-whole brain connectivity from a normative range derived from the control youths. The authors explored relationships between age-associated deviations in amygdala connectivity and positive symptoms in the psychosis spectrum group.
resultsNormative trajectories demonstrated significant age-related decreases in centromedial amygdala connectivity with distinct regions of the brain. In contrast, the psychosis spectrum group failed to exhibit any significant age-associated changes between the centromedial amygdala and the prefrontal cortices, striatum, occipital cortex, and thalamus (all q values <0.1). Age-associated deviations in centromedial amygdala-striatum and centromedial amygdala-occipital connectivity were unique to the psychosis spectrum group and were not observed in the other psychopathology group. Exploratory analyses revealed that greater age-related deviation in centromedial amygdala-thalamus connectivity was significantly associated with increased severity of positive symptoms (r=0.19; q=0.05) in the psychosis spectrum group.
conclusionsUsing neurodevelopmental growth charts to identify a lack of normative development of amygdala connectivity in youths with psychosis spectrum disorders may help us better understand the neural basis of affective impairments in psychosis, informing prediction models and interventions.
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