Evidence map›Paper›PMID 30654638›Full record

ArticleCell transplantation2019

Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?

Lyandysha V Zholudeva, Michael A Lane

Abstract read
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lyandysha V Zholudeva1 Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, USA.ORCID 0000-0003-4995-8466
Michael A Lane1 Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, USA.

Funding

SurgeryP01NS055976 · NINDS · DREXEL UNIVERSITY · PI TOM, VERONICA JEAN · 2007 to 2017
$12.3M
Neural transplants to promote respiratory plasticity after spinal cord injuryR01NS104291 · NINDS · DREXEL UNIVERSITY · PI LANE, MICHAEL ARON · 2018 to 2022
$1.7M
Optimizing functional recovery following cervical spinal cord injuryR01NS081112 · NINDS · UNIVERSITY OF FLORIDA · PI LANE, MICHAEL ARON · 2012 to 2015
$1.3M
NINDS NIH HHS P01 NS055976NINDS NIH HHS R01 NS081112NINDS NIH HHS R01 NS104291
6 · The paper itself

Abstract

Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise overview and discussion of five key themes that have become important considerations for rebuilding functional neural networks. The questions raised include: (i) who are the donor cells selected for transplantation, (ii) what is the intended target for repair, (iii) when is the optimal time for transplantation, (iv) where should the cells be delivered, and lastly (v) why does cell transplantation remain an attractive candidate for promoting neural repair after injury? Recent developments in neurobiology and engineering now enable us to start addressing these questions with multidisciplinary expertise and methods.

Indexed as

HumansSpinal Cord InjuriesSpinal Cord RegenerationStem Cell Transplantationcell transplantationinterneuronneural progenitorspinal cord injury

Identifiers

PMID30654638
PMCPMC6628562

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.