ArticleSensors (Basel, Switzerland)2019
Acoustic Stimulation by Shunt-Diode Pre-Linearizer using Very High Frequency Piezoelectric Transducer for Cancer Therapeutics.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
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- Novel dual-resistor-diode limiter circuit structures for high-voltage reliable ultrasound receiver systems.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- A New Approach to Power Efficiency Improvement of Ultrasonic Transmitters via a Dynamic Bias Technique.Sensors (Basel, Switzerland) · 2021Article
- Novel Bandwidth Expander Supported Power Amplifier for Wideband Ultrasound Transducer Devices.Sensors (Basel, Switzerland) · 2021Article
- Development of a low-cost six-axis alignment instrument for flexible 2D and 3D ultrasonic probes.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Inter-Stage Output Voltage Amplitude Improvement Circuit Integrated with Class-B Transmit Voltage Amplifier for Mobile Ultrasound Machines.Sensors (Basel, Switzerland) · 2020Article
- Post-Voltage-Boost Circuit-Supported Single-Ended Class-B Amplifier for Piezoelectric Transducer Applications.Sensors (Basel, Switzerland) · 2020Article
- Wireless Ultrasound Surgical System with Enhanced Power and Amplitude Performances.Sensors (Basel, Switzerland) · 2020Article
- Development of an Accurate Resonant Frequency Controlled Wire Ultrasound Surgical Instrument.Sensors (Basel, Switzerland) · 2020Article
- Wide Bandwidth Class-S Power Amplifiers for Ultrasonic Devices.Sensors (Basel, Switzerland) · 2020Article
- A Macro Lens-Based Optical System Design for Phototherapeutic Instrumentation.Sensors (Basel, Switzerland) · 2019Article
- Stacked Transistor Bias Circuit of Class-B Amplifier for Portable Ultrasound Systems.Sensors (Basel, Switzerland) · 2019Article
- Development of a Class-C Power Amplifier with Diode Expander Architecture for Point-of-Care Ultrasound Systems.Micromachines · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this paper, we proposed cancer cell acoustic stimulation by shunt-diode pre-linearizer scheme using a very high frequency (≥100 MHz) piezoelectric transducer. To verify the concept of our proposed scheme, we performed pulse-echo detection, and accessed therapeutic effects of human cervical cancer cells exposed to acoustic stimulation experiments using 100 MHz focused piezoelectric transducer triggered by PA with and without the proposed shunt-diode pre-linearizer scheme. In the pulse-echo detection responses, the peak-to-peak voltage of the echo signal when using the PA with shunt-diode pre-linearizer (49.79 mV) was higher than that when using the PA alone (29.87 mV). In the experimental results, the cell densities of cancer cells on Day 4 when using no acoustic stimulation (control group), the very high-frequency piezoelectric transducer triggered by PA only and PA combined with proposed pre-linearizer schemes (1 V and 5 V DC bias voltages) showed 100%, 92.8 ± 4.2%, 84.2 ± 4.6%, and 78 ± 2.9%, respectively. Therefore, we confirmed that the shunt-diode pre-linearizer could improve the performances of the pulse signals of the PA, thus, enabling better therapeutic stimulation performances for cancer cell suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.