Evidence map›Paper›PMID 30654540›Full record

ReviewInternational journal of molecular sciences2019

Stress Marks on the Genome: Use or Lose?

Bayan Bokhari, Sudha Sharma

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. DNA Damage Response and Oxidative Stress in Systemic Autoimmunity.International journal of molecular sciences · 2019
    Review
  12. Special Issue on DNA Replication Stress: Summary of Topics Covered.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bayan BokhariDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA. bayan.bokhari@bison.howard.edu.
Sudha SharmaDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA. sudha.sharma@howard.edu.ORCID 0000-0003-2765-2482

Funding

Advancing aging research through development of minority GerontologistsR25AG047843 · NIA · HOWARD UNIVERSITY · PI DUTTAROY, ATANU · 2014 to 2024
$3.3M
Molecular Analysis of RECQ1 Functions in Genome MaintenanceSC1GM093999 · NIGMS · HOWARD UNIVERSITY · PI SHARMA, SUDHA · 2010 to 2019
$3.0M
National Science Foundation NSF1832163NIGMS NIH HHS SC1 GM093999NIH HHS 1R25 AG047843NIH HHS SC1GM093999
6 · The paper itself

Abstract

Oxidative stress and the resulting damage to DNA are inevitable consequence of endogenous physiological processes further amplified by cellular responses to environmental exposures. If left unrepaired, oxidative DNA lesions can block essential processes such as transcription and replication or can induce mutations. Emerging data also indicate that oxidative base modifications such as 8-oxoG in gene promoters may serve as epigenetic marks, and/or provide a platform for coordination of the initial steps of DNA repair and the assembly of the transcriptional machinery to launch adequate gene expression alterations. Here, we briefly review the current understanding of oxidative lesions in genome stability maintenance and regulation of basal and inducible transcription.

Indexed as

GenomeOxidative StressAnimalsDNA DamageDNA ReplicationEpigenesis, GeneticHumansOxidation-Reduction8-oxoGDNA damageDNA repairepigeneticgene expressionhelicaseoxidative stressreplication

Identifiers

PMID30654540
PMCPMC6358951

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.