ReviewBrain sciences2019
Executive Function in Fragile X Syndrome: A Systematic Review.
Review in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- Repetitive Transcranial Magnetic Stimulation for Improving Cognitive Function in Patients With Mild Cognitive Impairment: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- [Neurocognitive profile and vulnerability for mental health problems in selected genetic syndromes with disorders of intellectual development].Der Nervenarzt · 2026Review
- Comparing feedback learning and arousal responses in Down, Fragile X, and Williams syndromes.NPJ science of learning · 2026Article
- A Novel Cooperative Behavior Assay in Rats Reveals Distinct Social Coordination Strategies of Increasing Complexity and Social Reciprocity Deficits in a Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The relationship between language and executive functions in adolescents with Down syndrome and fragile X syndrome.Journal of neurodevelopmental disorders · 2026Article
- Cerebral Cortex Morphometry and Relaxometry in Male Children With Fragile X Syndrome and Autism.Brain and behavior · 2026Article
- Planning for the Transition to Adulthood: Parent Perspectives on the Planning Process and Experiences of Young Adults with Fragile X Syndrome.Advances in neurodevelopmental disorders · 2026Article
- Article
- Intergenerational associations in inhibitory control inFrontiers in psychiatry · 2026Article
- Beyond Uniform Impairment: Investigating Declarative Memory Profiles in Nonspecific Mild Intellectual Disability Using Latent Profile Analysis.Journal of intellectual disability research : JIDR · 2025Observational
- Aberrant neural activation during inhibitory control in girls with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions.Frontiers in neuroscience · 2025Article
- Evidence of spontaneous mentalizing in children with Cornelia de Lange and fragile X syndromes, but not autistic children.Oxford open neuroscience · 2025Article
- Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism.Autism : the international journal of research and practice · 2024Article
- Developmental associations between cognition and adaptive behavior in intellectual and developmental disability.Journal of neurodevelopmental disorders · 2024Article
- Associations Between Executive Functioning, Behavioral Functioning, and Adaptive Functioning Difficulties in Wiedemann-Steiner Syndrome.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Developmental Associations between Cognition and Adaptive Behavior in Intellectual and Developmental Disability.Research square · 2024Article
- Developing improved outcome measures in FXS: Key stakeholder feedback.Research in developmental disabilities · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and is phenotypically characterized by EF deficits beyond what is expected given general cognitive impairments. Yet, a systematic review of behavioral studies using performance-based measures is needed to provide a summary of EF deficits across domains in males and females with FXS, discuss clinical and biological correlates of these EF deficits, identify critical limitations in available research, and offer suggestions for future studies in this area. Ultimately, this review aims to advance our understanding of the underlying pathophysiological mechanisms contributing to EF in FXS and to inform the development of outcome measures of EF and identification of new treatment targets in FXS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.