Evidence map›Paper›PMID 30654439›Full record

ReviewBioengineering (Basel, Switzerland)2019

Extracellular Vesicle Quantification and Characterization: Common Methods and Emerging Approaches.

Thomas A Hartjes, Serhii Mytnyk, Guido W Jenster, Volkert van Steijn, Martin E van Royen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Trial
  8. Review
  9. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas A HartjesDepartment of Pathology, Erasmus Optical Imaging Centre, Erasmus MC, 3015 GE Rotterdam, The Netherlands. t.hartjes@erasmusmc.nl.
Serhii MytnykDepartment of Chemical Engineering, Delft University of Technology, 3015 CD Delft, The Netherlands. S.Mytnyk@tudelft.nl.ORCID 0000-0002-0110-9433
Guido W JensterDepartment of Urology, Erasmus MC, 3015 CD Rotterdam, The Netherlands. g.jenster@erasmusmc.nl.ORCID 0000-0002-8658-2552
Volkert van SteijnDepartment of Chemical Engineering, Delft University of Technology, 3015 CD Delft, The Netherlands. V.vanSteijn@tudelft.nl.
Martin E van RoyenDepartment of Pathology, Erasmus Optical Imaging Centre, Erasmus MC, 3015 GE Rotterdam, The Netherlands. m.vanroyen@erasmusmc.nl.ORCID 0000-0002-6814-0996

Funding

Dutch Cancer Society EMCR2015-8022Dutch Cancer Society EMCR2017-8304NWO-TTW 14194Prostate Cancer UK G2012-36
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are a family of small membrane vesicles that carry information about cells by which they are secreted. Growing interest in the role of EVs in intercellular communication, but also in using their diagnostic, prognostic and therapeutic potential in (bio) medical applications, demands for accurate assessment of their biochemical and physical properties. In this review, we provide an overview of available technologies for EV analysis by describing their working principles, assessing their utility in EV research and summarising their potential and limitations. To emphasise the innovations in EV analysis, we also highlight the unique possibilities of emerging technologies with high potential for further development.

Indexed as

emerging technologiesExtracellular vesicles (EVs), methods for EV analysis

Identifiers

PMID30654439
PMCPMC6466085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.