ArticleRedox biology2019
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.
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Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
What it found
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Metabolic Modulation by Dimethyl Fumarate Alters Docetaxel Responses in Prostate Cancer Cells.International journal of molecular sciences · 2026Article
- Engineering de novo formatotrophy in the non-model yeastNature synthesis · 2026Article
- Modulation of Nrf2 and Mitochondrial Function: Pharmacological Implications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Protective effect and molecular mechanisms of magnolol in ischemic stroke.Pharmacological reports : PR · 2025Review
- Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation.Biomolecules · 2025Review
- Regio- and Stereoselective Synthesis of Nitro-fatty Acids as NRF2 Pathway Activators Working under Ambient or Hypoxic Conditions.Journal of medicinal chemistry · 2025Article
- Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum.Veterinary research · 2025Article
- Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels.Frontiers in physiology · 2025Article
- Nebulized Glutathione as a Key Antioxidant for the Treatment of Oxidative Stress in Neurodegenerative Conditions.Nutrients · 2024Review
- Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.Nature communications · 2024Article
- Dimethyl Fumarate Mediates Sustained Vascular Smooth Muscle Cell Remodeling in a Mouse Model of Cerebral Aneurysm.Antioxidants (Basel, Switzerland) · 2024Article
- The Role of Nrf2 in the Regulation of Mitochondrial Function and Ferroptosis in Pancreatic Cancer.Antioxidants (Basel, Switzerland) · 2024Review
- The implications of exercise in Drosophila melanogaster: insights into Akt/p38 MAPK/Nrf2 pathway associated with Hsp70 regulation in redox balance maintenance.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- NRF2, a Superstar of Ferroptosis.Antioxidants (Basel, Switzerland) · 2023Review
- Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies.Antioxidants (Basel, Switzerland) · 2023Review
- Distinct effects of intracellular vs. extracellular acidic pH on the cardiac metabolome during ischemia and reperfusion.Journal of molecular and cellular cardiology · 2023Article
- Review
- Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite.Antioxidants (Basel, Switzerland) · 2022Review
- Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Soma JobbagyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Dario A VitturiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Sonia R SalvatoreDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Lucía TurellLaboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias and Center for Free Radical and Biomedical Research, Universidad de la República, Montevideo, Uruguay.
Maria F PiresDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Emilia KansanenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Carlos BatthyanyPasteur Institut, Montevideo, Uruguay.
Jack R LancasterDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States; Departments of Surgery and Medicine, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address: fjs2@pitt.edu.
University of Pittsburgh · USInstitut Pasteur de Montevideo · UYUniversidad de la República · UYUniversity of Eastern Finland · FI
Funding
Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIVA, SRUTI · 2011 to 2020
$26.1MTranslational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3MRedox-Derived Pulmonary Anti-Inflammatory MediatorsR01HL064937 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2000 to 2015
$5.6MRedox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2MFormation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4MAnti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9MPredominant protective role in hepatic steatosis and obesity by fish oil-derived furansR01DK112854 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2021
$1.6MProtection against sickle cell disease nephropathy by nitrated fatty acidsK01HL133331 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VITTURI, DARIO A · 2016 to 2021
$848kProtective effects of nitro-oleic acid in hypertensive chronic kidney injuryF30DK108391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOBBAGY, SOMA · 2015 to 2018
$195kNHLBI NIH HHS K01 HL133331NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL064937NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R37 HL058115NHLBI NIH HHS T32 HL007563NIDDK NIH HHS F30 DK108391NIDDK NIH HHS R01 DK112854NIGMS NIH HHS R01 GM125944
Abstract
Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic acid (NO
Indexed as
AlgorithmsAlkylationAmino Acid SequenceAnimalsATP-Binding Cassette, Sub-Family C ProteinsCatalysisCatalytic DomainGlutathioneGlutathione DisulfideGlutathione ReductaseIntracellular SpaceKineticsMiceModels, TheoreticalNF-E2-Related Factor 2Nitric OxideATP-Binding Cassette, Sub-Family C ProteinsGlutathioneGlutathione DisulfideGlutathione Reductasemultidrug resistance-associated protein 1NF-E2-Related Factor 2Nitric OxideReactive Oxygen SpeciesSulfhydryl CompoundsDisulfideElectrophileGlutathioneGlutathione reductaseNitrated fatty acidNrf2Oxidation-reduction (redox)Thiol
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.