ArticleTranslational research : the journal of laboratory and clinical medicine2019
Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits.
Article in Translational research : the journal of laboratory and clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Birth outcomes following intrauterine exposure to electronic nicotine delivery systems: a systematic review and meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Prevalence of dual use of combustible tobacco and E-cigarettes among pregnant smokers: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- The Effects of E-Cigarette Vapor Components on the Morphology and Function of the Male and Female Reproductive Systems: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Uterine artery transcriptomic signatures of e-cigarette aerosol exposure in pregnancy.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Vaping during pregnancy and maternal, fetal, and infant health outcomes: A scoping review of human and animal studies.PloS one · 2026Article
- Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026Review
- Nicotine influence on cerebrovascular and neurocognitive function with in utero electronic cigarette exposure.The Journal of physiology · 2025Article
- E-Cigarette and Vanillin Exposure Disrupts Cardiovascular Development in Xenopus laevis.Birth defects research · 2025Article
- Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.Cardiovascular toxicology · 2025Review
- Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.Cardiovascular toxicology · 2025Article
- Long-Term Neurologic Consequences following Fetal Growth Restriction: The Impact on Brain Reserve.Developmental neuroscience · 2025Review
- Altered uterine artery protein signature and function following E-cigarette exposure in pregnancy.American journal of translational research · 2025Article
- Intrapartum Electronic Cigarette Use and Birth Outcomes: Evidence from a Population-Based Study.International journal of environmental research and public health · 2024Article
- Fetal Growth Following Electronic Cigarette Use in Pregnancy.International journal of environmental research and public health · 2024Article
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes.The Journal of physiology · 2024Article
- Maternal use of electronic cigarettes and impact on offspring: a double-hit model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Gestation, Not Lactation, Is to Blame for Postnatal Vascular Dysfunction in Offspring With Maternal Electronic Cigarette Exposure.Journal of the American Heart Association · 2024Article
- Vaping-Dependent Pulmonary Inflammation Is CaInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Increasing popularity of electronic cigarettes (e-cigs), including among women of reproductive age, is attributed to its perceived safety compared to conventional tobacco. However, there is a major knowledge gap surrounding the effects of e-cig aerosols on pregnancy and fetal development. We aimed to evaluate the effects of vaping e-cigs during gestation on offspring growth and to asses if growth deficits are accompanied by altered maternal and fetal vascular hemodynamics. Sprague-Dawley dams were assigned to Pair-Fed Control, Pair-Fed Juice, or Juice+Nicotine groups, and then underwent either a prenatal or prenatal+postnatal exposure paradigm in a custom-engineered vaping system. Mass spectrometry identified major aerosolized constituents from e-cig vaping. The Juice+Nicotine group exhibited significantly decreased fetal weight and crown-rump length (↓46.56%, and ↓23.83%, respectively). Pre- and postnatal exposure to Juice+Nicotine resulted in decreased pup weight at postnatal day (PND) 4-10. Crown-rump length was decreased by 24.71% on PND 10. Blood flow in the Juice+Nicotine group was decreased in the maternal uterine and fetal umbilical circuits by 49.50% and 65.33%, respectively. We conclude that chronic exposure to e-cig aerosols containing nicotine during early development can have deleterious health effects on the exposed offspring. Vaping e-cigs containing nicotine during pregnancy lead to a reduction in offspring weight and crown-rump length, associated with a marked decrease in blood flow in both the maternal uterine and fetal umbilical circulation (a strong indicator of growth restriction). Thus, chronic exposure to e-cig aerosols containing nicotine can lead to potentially harmful developmental effects in early life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.