Evidence map›Paper›PMID 30653936›Full record

ArticleNeuron2019

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.

Bahareh Eftekharzadeh, J Gavin Daigle, Larisa E Kapinos, Alyssa Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean J Miller, Simon Dujardin, Ana S Amaral and 20 more

Abstract readPublished Erratum
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Nuclear transport proteins: structure, function, and disease relevance.Signal transduction and targeted therapy · 2023
    Review
  9. Article
  10. Article
  11. The prion-like transmission of tau oligomersFrontiers in aging neuroscience · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Bahareh Eftekharzadeh
J Gavin Daigle
Larisa E Kapinos
Alyssa Coyne
Julia Schiantarelli
Yari Carlomagno
Casey Cook
Sean J Miller
Simon Dujardin
Ana S Amaral
Jonathan C Grima
Rachel E Bennett
Katharina Tepper
Michael DeTure
Charles R Vanderburg
Bianca T Corjuc
Sarah L DeVos
Jose Antonio Gonzalez
Jeannie Chew
Svetlana Vidensky
Fred H Gage
Jerome Mertens
Juan Troncoso
Eckhard Mandelkow
Xavier Salvatella
Roderick Y H Lim
Leonard Petrucelli
Susanne Wegmann
Jeffrey D Rothstein
Bradley T Hyman

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Validation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker developmentP01NS099114 · NINDS · UNIVERSITY OF FLORIDA · PI DISNEY, MATTHEW D, PETRUCELLI, LEONARD · 2017 to 2021
$6.5M
Project 2: Identifying genes and Pathways that impact Tau Toxicity in FTDU54NS100693 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2016 to 2020
$6.2M
Training in Neurostatistics and NeuroepidemiologyT32NS048005 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ONNELA, JUKKA-PEKKA · 2004 to 2018
$3.2M
The Nuclear Pore Complex in ALS/FTDF31NS103360 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GRIMA, JONATHAN · 2017 to 2018
$89k
NIGMS NIH HHS T32 GM008752NINDS NIH HHS F31 NS103360NINDS NIH HHS P01 NS099114NINDS NIH HHS T32 NS048005NINDS NIH HHS U54 NS100693
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30653936
PMCPMC6377243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.