ArticleHuman brain mapping2019
The supplementary motor area modulates interhemispheric interactions during movement preparation.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02073604 (Rôle de la SMA Dans la préparation Des Mouvements Uni et Bi-manuels), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rôle de la SMA Dans la préparation Des Mouvements Uni et Bi-manuels: le Paradigme Des Mouvements en Miroir
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Oscillatory dynamics of motor learning across adulthood life span: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI).Brain structure & function · 2023Pooled it
- [Paresis of an upper extremity. Action observation and motor imagery in recovery of patients with chronic stroke].Revista de neurologia · 2024Trial
- Distinct neural responses to punishment anticipation in violent and non-violent individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Supplementary Motor Area During Motor Actions in Athletes With Neurological Disorders: Observational Study of Cases and Controls.Brain and behavior · 2026Observational
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Continuous Theta Burst to Supplementary Motor Area Modulates Groove.Annals of the New York Academy of Sciences · 2026Article
- Functional Near-Infrared Spectroscopy Reveals Functional Rewiring between Macaque Motor Areas Following Postinfarction Recovery of Manual Dexterity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Investigating the effects of age and conditioning stimulation intensity on SMA-M1 connectivity in younger, middle-aged, and older adults.European journal of applied physiology · 2026Article
- Resting-state brain activity and association with physical activity.Frontiers in aging neuroscience · 2026Article
- Amygdala functional connectivity and response to aerobic exercise in subthreshold depression-an exploratory fMRI study.BMC psychiatry · 2025Article
- The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning: A TMS and TMS-EEG Study.Neuroscience bulletin · 2025Article
- Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI.BMC medical imaging · 2025Article
- Widespread neuronal activity related to bimanual coordination in non-human primates: evidence from Fos-like activation during bimanual versus unimanual motor task.Neuroscience insights · 2025Article
- Age-related GABA- and glutamatergic differences in SMA during bimanual coordination.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Executive dysfunctions in patients with low-grade gliomas in the supplementary motor area: a neuropsychological perspective.Frontiers in human neuroscience · 2025Article
- Functional Connectivity Profiles of Ten Sub-Regions within the Premotor and Supplementary Motor Areas: Insights into Neurophysiological Integration.Diagnostics (Basel, Switzerland) · 2024Article
- Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- Cortico-striatal activity associated with fidget spinner use: an fMRI study.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 2 countries.
Funding
Abstract
The execution of coordinated hand movements requires complex interactions between premotor and primary motor areas in the two hemispheres. The supplementary motor area (SMA) is involved in movement preparation and bimanual coordination. How the SMA controls bimanual coordination remains unclear, although there is evidence suggesting that the SMA could modulate interhemispheric interactions. With a delayed-response task, we investigated interhemispheric interactions underlying normal movement preparation and the role of the SMA in these interactions during the delay period of unimanual or bimanual hand movements. We used functional MRI and transcranial magnetic stimulation in 22 healthy volunteers (HVs), and then in two models of SMA dysfunction: (a) in the same group of HVs after transient disruption of the right SMA proper by continuous transcranial magnetic theta-burst stimulation; (b) in a group of 22 patients with congenital mirror movements (CMM), whose inability to produce asymmetric hand movements is associated with SMA dysfunction. In HVs, interhemispheric connectivity during the delay period was modulated according to whether or not hand coordination was required for the forthcoming movement. In HVs following SMA disruption and in CMM patients, interhemispheric connectivity was modified during the delay period and the interhemispheric inhibition was decreased. Using two models of SMA dysfunction, we showed that the SMA modulates interhemispheric interactions during movement preparation. This unveils a new role for the SMA and highlights its importance in coordinated movement preparation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.