Evidence map›Paper›PMID 30653734›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2019

The association between lifestyle factors and Parkinson's disease progression and mortality.

Kimberly C Paul, Yu-Hsuan Chuang, I-Fan Shih, Adrienne Keener, Yvette Bordelon, Jeff M Bronstein, Beate Ritz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Reply to: "Alcohol Intake and Parkinson's Symptoms Following Diagnosis".Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  9. Alcohol Intake and Parkinson Symptoms Following Diagnosis.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  10. Review
  11. Review
  12. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  13. Review
  14. Article
  15. Association between alcohol consumption and mortality in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease.Annals of clinical and translational neurology · 2025
    Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kimberly C PaulDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.ORCID 0000-0002-4476-2352
Yu-Hsuan ChuangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
I-Fan ShihDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Adrienne KeenerDepartment of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.ORCID 0000-0003-1930-6619
Yvette BordelonDepartment of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.
Jeff M BronsteinDepartment of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
University of California, Los Angeles · USUCLA Health · US

Funding

Center for Gene-Environment Studies in Parkinson DiseaseU54ES012078 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2002 to 2006
$7.1M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Environmental Predictors of the Overlap of Neurodegenerative Disorders and Metabolic DysfunctionF32ES028087 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KIMBERLY · 2017 to 2018
$121k
American Parkinson's Disease Association (APDA)Levine FoundationNational Institute of Environmental Health Science F32-ES028087National Institute of Environmental Health Science R01-ES010544National Institute of Environmental Health Science U54-ES012078NIEHS NIH HHS F32 ES028087NIEHS NIH HHS L30 ES029738NIEHS NIH HHS R01 ES010544NIEHS NIH HHS U54 ES012078Parkinson AllianceVeterans Administration Healthcare System (SW PADRECC)
6 · The paper itself

Abstract

backgroundLifestyle factors may contribute to the development of Parkinson's disease, but little is known about factors that influence progression. The objective of the current study was to examine whether caffeine or alcohol consumption, physical activity, or cigarette smoking is associated with progression and survival among PD patients.

methodsWe assessed lifelong coffee, tea, and alcohol consumption, smoking, and physical activity in a prospective community-based cohort (n = 360). All patients were passively followed for mortality (2001-2016); 244 were actively followed on average ± SD 5.3 ± 2.1 years (2007-2014). Movement disorder specialists repeatedly assessed motor function (Hoehn & Yahr) and cognition (Mini-Mental State Exam). We used Cox proportional hazards models and inverse probability weights to account for censoring.

resultsCoffee, caffeinated tea, moderate alcohol consumption, and physical activity were protective against at least 1 outcome. Smoking and heavy alcohol consumption were associated with increased risks. Coffee was protective against time to Hoehn & Yahr stage 3 (hazard ratio, 0.52; 95% confidence interval, 0.28-1.01), cognitive decline (hazard ratio, 0.23; 95% confidence interval, 0.11, 0.48), and mortality (hazard ratio, 0.47; 95% confidence interval, 0.32-0.69). Relative to moderate drinkers, those who never drank liquor and those who drank more heavily were at an increased risk of Hoehn & Yahr 3 (hazard ratio, 3.48; 95% confidence interval, 1.90-6.38; and hazard ratio, 2.16; 95% confidence interval, 1.03, 4.54, respectively). A history of competitive sports was protective against cognitive decline (hazard ratio, 0.46; 95% confidence interval, 0.22-0.96) and Hoehn & Yahr 3 (hazard ratio, 0.42; 95% confidence interval, 0.23-0.79), as was physical activity measured by metabolic-equivalent hours. Current cigarette smoking was associated with faster cognitive decline (hazard ratio, 3.20; 95% confidence interval, 1.02-10.01).

conclusionsThis population-based study suggests that lifestyle factors influence PD progression and mortality. © 2019 International Parkinson and Movement Disorder Society.

Indexed as

Life StyleAgedAlcohol DrinkingCaffeineCoffeeDisease ProgressionExerciseFemaleHumansMaleMiddle AgedParkinson DiseaseRisk FactorsSmokingCaffeineCoffeealcoholcoffeecognitionParkinson's diseaseprogression

Identifiers

PMID30653734
PMCPMC6544143
OpenAlexW2909667856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.