Evidence map›Paper›PMID 30653618›Full record

ArticlePloS one2019

PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes.

Camille E Pinguet, Esther Ryll, Alexander A Steinschulte, Jón M Hoffmann, Monia Brugnoni, Andrey Sybachin, Dominik Wöll, Alexander Yaroslavov, Walter Richtering, Felix A Plamper

Abstract read
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In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Camille E PinguetInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Esther RyllInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Alexander A SteinschulteInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Jón M HoffmannInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Monia BrugnoniInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-2220-3645
Andrey SybachinDepartment of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation.
Dominik WöllInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Alexander YaroslavovDepartment of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation.
Walter RichteringInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.
Felix A PlamperInstitute of Physical Chemistry, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-0762-6095

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl methacrylate) (qPDMAEMA100)3.1). The combined action of (qPDMAEMA100)3.1 and a nonionic star-shaped polymer (PEO12-b-PPO45)4, which comprises diblock copolymer arms uniting a poly(ethylene oxide) PEO inner block and a poly(propylene oxide) PPO terminal block, leads to a stabilization of these complexes against disintegration in saline solutions. Hereby, the anchoring of the PPO terminal blocks to the lipid bilayer and the bridging between several liposomes are at the origin of the promoted structural stability. Two-focus fluorescence correlation spectroscopy verifies the formation of multiliposomal complexes with (PEO12-b-PPO45)4. The polyelectrolyte and the amphiphilic polymer work synergistically, as the joint action still assures some membrane integrity, which is not seen for the mere (PEO12-b-PPO45)4-liposome interaction alone.

Indexed as

Cryoelectron MicroscopyLipid BilayersMolecular ConformationMolecular StructurePhenyl EthersPolyelectrolytesPolyethylene GlycolsPolymersStatic ElectricityUnilamellar LiposomesLipid BilayersPhenyl Etherspoly(2,6-dimethyl-1,4-phenylene oxide)PolyelectrolytesPolyethylene GlycolsPolymersUnilamellar Liposomes

Identifiers

PMID30653618
PMCPMC6336312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.