ArticlePloS one2019
Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Trial
- Hypoperfusion in early-phase amyloid PET as a predictor of cognitive decline in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2026Article
- A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism usingNeuroImage. Clinical · 2026Article
- Correlation and Interchangeability of Amyloid, Tau, and Glucose Metabolism PET in Mild Cognitive Impairment and Alzheimer: A Review.Brain sciences · 2025Review
- Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Evaluation of early-phaseJournal of Alzheimer's disease : JAD · 2025Article
- Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Machine learning model for predicting Amyloid-β positivity and cognitive status using early-phaseScientific reports · 2025Article
- Early-phaseEuropean journal of nuclear medicine and molecular imaging · 2025Article
- Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography.Addiction biology · 2025Article
- Elevated cerebral blood flow proxy with increased beta-amyloid burden in Alzheimer's disease preclinical phase evaluated by dual-phaseScientific reports · 2024Article
- Head-to-head comparison of relative cerebral blood flow derived from dynamic [EJNMMI research · 2023Article
- Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study.European journal of nuclear medicine and molecular imaging · 2023Article
- Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Article
- Early-phaseJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Alzheimer's disease pattern derived from relative cerebral flow as an alternative for the metabolic pattern using SSM/PCA.EJNMMI research · 2022Article
- Design, Synthesis, and Preliminary Evaluation of [Bioconjugate chemistry · 2022Article
- Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2022Article
- Dynamic Amyloid PET: Relationships toJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) and 11C-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-β deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R1) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method's distributions were seen as well. Also, a better correlation with FDG was found for R1 than for ePIB. Further studies are needed to validate the use of R1 as an alternative for FDG studies in clinical applications.
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