ArticlePloS one2019
Central modulation of parasympathetic outflow is impaired in de novo Parkinson's disease patients.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review.Journal of neurology · 2024Pooled it
- Sympathetic Shift and Insular Alteration: Unravelling the Link Between Anxiety and Heart Rate Variability in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Multimodal MRI to elucidate cross-organ coupling mechanisms of the heart-brain axis.Frontiers in cardiovascular medicine · 2026Review
- The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways.Nature reviews. Cardiology · 2025Review
- Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.EJNMMI research · 2024Article
- Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Characterizing cardiac autonomic dynamics of fear learning in humans.Psychophysiology · 2022Article
- Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms.Brain sciences · 2022Review
- Heart-brain synchronization breakdown in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease.Scientific reports · 2022Article
- Resting-state functional magnetic resonance imaging in patients with Parkinson's disease with and without constipation: a prospective study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Article
- Effect of data leakage in brain MRI classification using 2D convolutional neural networks.Scientific reports · 2021Article
- Assessment of Functions of the Autonomic Nervous System in the Elderly with Different Comorbid Factors.Journal of neurosciences in rural practice · 2021Article
- Uncovering complex central autonomic networks at rest: a functional magnetic resonance imaging study on complex cardiovascular oscillations.Journal of the Royal Society, Interface · 2020Article
- mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson's disease.NPJ digital medicine · 2020Article
- Causal influence of brainstem response to transcutaneous vagus nerve stimulation on cardiovagal outflow.Brain stimulationArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Task- and stimulus-based neuroimaging studies have begun to unveil the central autonomic network which modulates autonomic nervous system activity. In the present study, we aimed to evaluate the central autonomic network without the bias constituted by the use of a task. Additionally, we assessed whether this circuitry presents signs of dysregulation in the early stages of Parkinson's disease (PD), a condition which may be associated with dysautonomia. We combined heart-rate-variability based methods for time-varying assessments of the autonomic nervous system outflow with resting-state fMRI in 14 healthy controls and 14 de novo PD patients, evaluating the correlations between fMRI time-series and the instantaneous high-frequency component of the heart-rate-variability power spectrum, a marker of parasympathetic outflow. In control subjects, the high-frequency component of the heart-rate-variability power spectrum was significantly anti-correlated with fMRI time-series in several cortical, subcortical and brainstem regions. This complex central network was not detectable in PD patients. In between-group analysis, we found that in healthy controls the brain activation related to the high-frequency component of the heart-rate-variability power spectrum was significantly less than in PD patients in the mid and anterior cingulum, sensorimotor cortex and supplementary motor area, insula and temporal lobe, prefrontal cortex, hippocampus and in a region encompassing posterior cingulum, precuneus and parieto-occipital cortex. Our results indicate that the complex central network which modulates parasympathetic outflow in the resting state is impaired in the early clinical stages of PD.
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