ArticlePLoS biology2019
Avoidance response to CO2 in the lateral horn.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
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- How honey bees make fast and accurate decisions.eLife · 2023Article
- Behavioral algorithms and neural mechanisms underlying odor-modulated locomotion in insects.The Journal of experimental biology · 2023Review
- Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding ineLife · 2022Article
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- Drosophila melanogaster Stress Odorant (dSO) Displays the Characteristics of an Interspecific Alarm Cue.Journal of chemical ecology · 2021Article
- Interneuronal mechanisms for learning-induced switch in a sensory response that anticipates changes in behavioral outcomes.Current biology : CB · 2021Article
- Article
- Olfactory processing in the lateral horn of Drosophila.Cell and tissue research · 2021Review
- Neuronal architecture of the second-order COScientific reports · 2020Article
- Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.Current biology : CB · 2020Article
- Differential Role for a Defined Lateral Horn Neuron Subset in Naïve Odor Valence in Drosophila.Scientific reports · 2020Article
- Neurogenetic dissection of theeLife · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In flies, the olfactory information is carried from the first relay in the brain, the antennal lobe, to the mushroom body (MB) and the lateral horn (LH). Olfactory associations are formed in the MB. The LH was ascribed a role in innate responses based on the stereotyped connectivity with the antennal lobe, stereotyped physiological responses to odors, and MB silencing experiments. Direct evidence for the functional role of the LH is still missing. Here, we investigate the behavioral role of the LH neurons (LHNs) directly, using the CO2 response as a paradigm. Our results show the involvement of the LH in innate responses. Specifically, we demonstrate that activity in two sets of neurons is required for the full behavioral response to CO2. Tests of the behavioral response to other odors indicate the neurons are selective to CO2 response. Using calcium imaging, we observe that the two sets of neurons respond to CO2 in a different manner. Using independent manipulation and recording of the two sets of neurons, we find that the one that projects to the superior intermediate protocerebrum (SIP) also outputs to the local neurons within the LH. The design of simultaneous output at the LH and the SIP, an output of the MB, allows for coordination between innate and learned responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.